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IgG4, CD4s and why the LNP/mRNA platform should be prohibited
Immunological shift to tolerance and reliance on/persistent activation of CD4+ T cells
This is going to be very quick and dirty.
Papers for homework reading:
Kiszel P, Sík P, Miklós J, Kajdácsi E, Sinkovits G, Cervenak L, Prohászka Z. Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history. Sci Rep. 2023 Aug 13;13(1):13166. doi: 10.1038/s41598-023-40103-x. PMID: 37574522.
Uversky VN, Redwan EM, Makis W, Rubio-Casillas A. IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein. Vaccines (Basel). 2023 May 17;11(5):991. doi: 10.3390/vaccines11050991. PMID: 37243095; PMCID: PMC10222767.
Della-Torre E, Lanzillotta M, Strollo M, Ramirez GA, Dagna L, Tresoldi M; COVID-BioB study group. Serum IgG4 level predicts COVID-19 related mortality. Eur J Intern Med. 2021 Nov;93:107-109. doi: 10.1016/j.ejim.2021.09.012. Epub 2021 Sep 24. PMID: 34598853; PMCID: PMC8461218.
The first in the line is the most recent paper published in Nature and it shows that if you’re injected with modified mRNA COVID-19 products, as opposed to vector-based vaccines, and subsequently infected with COVID-19, as opposed to having had prior exposure, your IgG4 profile will be totally different than if it’s the other way around. By different, I mean you will have a high proportion of spike-specific IgG4 antibody responses.
Immune memory and the generation of specific class-switched antibodies are mainly dependent on T-cell responses. Robust and persistent follicular helper T-cell (Tfh) response has also been described in lymph nodes of individuals vaccinated by Pfizer-BioNTech vaccine.
Yes, they are.
Follicular helper T cells (also known as follicular B helper T cells), are antigen-experienced CD4+ T cells found in the periphery within B cell follicles of secondary lymphoid organs such as lymph nodes, spleen and Peyer's patches, and are identified by their constitutive expression of the B cell follicle homing receptor CXCR5.
Tfh cells are vital to the support of germinal centers and the generation of immunological memory. Also and of great importance,
Overactive Tfh cell immune responses have the potential to mount unwarranted germinal centers, composed of aberrantly mutated B cells that can drive antibody-mediated autoimmune diseases.
Think about that.
Injection with the modified mRNA products induces (follicular) helper T cell ‘responses’. This means these cells are activated to respond to express cell surface receptors, secrete cytokines, chemokines and to provide aid to and activate other cell types like CTLs and macrophages, especially B cells.
It has been shown that the mRNA and the spike are persistent. Since these are foreign antigens, they will continually stimulate the immune system to respond in turn. A perpetual state of activation is bad. It leads to a hyper-inflamed state, senescence and exhaustion. I hinted about this before (and I will review the SARS-2/CD4 paper) and it is my opinion now that CD4+ T helper cells, including Tfh cells, are being perpetually activated by the LNP/spike system to express various surface receptors to aid in the generation of spike-specific IgG4 antibodies via the generation of IgG1 and IgG4 positive memory B cells via stimulation of intracellular TLR3, TLR7 and TLR9 in B cells.1 PEG causes increased immunogenicity on its own, and the modified mRNA products stimulate these TLRs (Toll-like receptors).
I am almost positive at this point that these modified mRNA injections are inducing senescence and exhaustion.
The bottom line here, once again, is that there is mounting (in fact, a mountain of) evidence that the modified mRNA shots IN PARTICULAR, induce immune dysfunction (and tolerance) to the detriment of human physiology. This is NOT refutable, no matter how many individuals profiting from this dare to claim that these products are safe. They are not.
Prove that they are.
If you got injected with the modified mRNA products, you’re likely more susceptible to SARS-CoV-2 and the detrimental effects of subsequent COVID-19. This is due to the direct effects of the LNPs and the modified mRNA/spike (likely continuously expressed) on the modification and dysfunction enacted on the innate and acquired immune system branches.
In this particular article, they show injection-induced high proportion of spike-specific IgG4 antibody responses. This is incredibly important to investigate further since, as most of my readers know, millions of people injected with the modified mRNA products have been injured as reflected in our many pharmacovigilance databases (including VAERS).
To date, ~1.57 million reports of adverse events have been filed to VAERS alone in the context of the COVID-19 injectable products. This is without considering the under-reporting factor. This is in ridiculously stark contrast to historical values reported for all vaccines combined.
Of these, 15% reported also having COVID-19. This only represents those who reported symptoms at the time that the VAERS report was filed.
This really was quick and dirty. But I needed to write some of it down.
Sackesen, C. et al. Suppression of B-cell activation and IgE, IgA, IgG1 and IgG4 production by mammalian telomeric oligonucleotides. Allergy 68, 593–603. https://doi.org/10.1111/all.12133 (2013).