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"IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein"
Who said what now?
Please refer to the newly published paper entitled: “IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein”1 published in Vaccines on May 17, 2023. The paper has remarkable findings and concludes that:
Increased IgG4 synthesis due to repeated mRNA vaccination with high antigen concentrations may also cause autoimmune diseases, and promote cancer growth and autoimmune myocarditis in susceptible individuals.
Promote cancer growth eh? Hmm. Didn’t someone write this up recently and get a lot a flack for it? I am sure someone did.
This newest paper provides even more evidence to support the claim that the shift to the IgG4 subtype seen in the context of the COVID mRNA shots promotes cancer by immune evasion techniques.
IgG4 antibody is important and necessary for cancer immune evasion. In a cohort of individuals with esophageal cancer, B cells producing high IgG4 concentrations were markedly raised in malignant cells and also high in serum samples from patients. More IgG4 seems to be linked to more aggressive cancer growth, and both were strongly associated with higher cancer malignancy and poor prognosis. It was discovered that IgG4 can contend with IgG1 (as shown in Figure 3) in binding to Fc receptors present in some immune cells in vitro. This competition results in the inhibition of typical immune responses against cancer cells, such as cell and complement cytotoxicity and cell phagocytosis, which are mediated by IgG1 antibodies.
So as I stated in my previous article,
The unique ability of this typically rare subclass of antibody to switch out its arms, makes it unable to act out the things that I described above that IgG1 can do. Namely, form immune complexes and bind receptors on cells for removal of unwanted cells. So those three ways: the ADCC, ADCP and CDC - that aid in removal of unwanted cells are all nullified in the scenario where IgG4 is prevalent. Worse than that, since the subclass switch is literally the by-product of continuous antigen stimulation, then this is an immunological endorsement of a ‘win’ for IgG4 if we consider competition for binding sites. In effect, IgG4 outcompetes IgG1 and thus, the scales tip from tumor suppression, to tumor progression. All because of IgG4.
And my take home message was:
This could be potentiating relapses of cancers previously in remission and also new and rare cancer appearances.
The paper also brings up some interesting factoids about other injectable products such as vaccines against HIV, malaria and Pertussis. What this means to me is that, once again, there was clear proof of concept in the realm of an immune tolerance mechanism inducible by vaccines (and thus also potentially by mRNA products), which could have many negative and unintended consequences. the fact that we knew this could happen, should have warranted a little more of that precautionary principle thing.
Could this increase in IgG4 levels explain the reduced efficacy of mRNA vaccines detected after 6 months ? Based on findings from the HIV trial , where decreased vaccine efficacy was linked to IgG4 production, we conclude that repeated mRNA vaccination is also correlated with reduced efficacy in protecting people from re-infection due to an increase in IgG4 levels.
These consequences include tolerance to spike protein, impairing interferon signaling and rendering one susceptible to other infections/diseases, immune suppression, autoimmunity including autoimmune myocarditis and are you ready for this: a chronic disease state comparable to that of HIV, HBV and HCV. I have also proposed this as I believe this is precisely what we are seeing. If this is correct, then we will be seeing many more reports of delayed effects in the future.
Now this paper is remarkable for more reasons than its content. The authors actually are so bold as to state the following without the typical high fructose corn syrup coating:
“[Injection] [142,143,144]) could explain a plethora of autoimmune conditions, such as cancers, re-infections, and deaths temporally associated with both. It is conceivable that the excess deaths reported in several highly COVID-19-vaccinated countries may be explained, in part, by this combined immunosuppressive effect.”
“Indeed, several investigations have found that COVID-19 immunization is associated with the development of autoimmune responses [148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165,166].”
“[It] is plausible to suggest that excessive vaccination could be associated with the occurrence of an increased number of myocarditis cases and sudden cardiac deaths.”
“Paradox: if people who are the most affected by the COVID-19 disease (the elderly, diabetics, hypertensive, and immunocompromised people like those with HIV) are also more susceptible to suffering the negative effects of repeated mRNA vaccination, is it then justified to booster them?”
“This research also showed that immunity acquired through natural disease provides better protection against infection and disease symptoms caused by the Delta variant of SARS-CoV-2 than the immunity provided by two injections with the BNT162b2 vaccine .”
“Locally elevated levels of IgG4 in cancer tissue hindered antibody-mediated anticancer responses, assisted cancer in blocking the local immune response and indirectly aided in cancer progression.”
I think the authors did a splendid job here.
Uversky VN, Redwan EM, Makis W, Rubio-Casillas A. IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein. Vaccines. 2023; 11(5):991. https://doi.org/10.3390/vaccines11050991.
Crescioli S, Correa I, Karagiannis P, Davies AM, Sutton BJ, Nestle FO, Karagiannis SN. IgG4 Characteristics and Functions in Cancer Immunity. Curr Allergy Asthma Rep. 2016 Jan;16(1):7. doi: 10.1007/s11882-015-0580-7. PMID: 26742760; PMCID: PMC4705142.
Schuurman J, Labrijn AF, Parren PW. Fab-arm exchange: what's in a name? MAbs. 2012 Nov-Dec;4(6):636. doi: 10.4161/mabs.22075. Epub 2012 Sep 6. PMID: 22955209; PMCID: PMC3502229.
Koneczny I (2018) A New Classification System for IgG4 Autoantibodies. Front. Immunol. 9:97. doi: 10.3389/fimmu.2018.00097.
Ulrike Herbrand. Antibody-Dependent Cellular Phagocytosis: The Mechanism of Action That Gets No Respect A Discussion About Improving Bioassay Reproducibility. Spring 2016 BioProcessing Journal [Vol.15/No.1] 26 Since 2002.