VAERS reports of Haemophagocytic lymphohistiocytosis
VAERS reports of Haemophagocytic lymphohistiocytosis
There is something going on here.
Only a few hours ago I wrote an article about my attention being brought to a rare syndrome called HLH.
The disease is classified as either primary (the result of inherited genetic mutations) or secondary (an inappropriate host response to infection, malignancy, or autoimmune disease).1
The pathophysiology involves the dysregulation of NK cells of the innate immune system and CD8+ cytotoxic T-cells of the acquired whereby perforin and granzyme production is faulty. (Ref #1)
I decided to write this follow-up piece immediately because in my original query of this syndrome in VAERS, I had mis-spelled ‘Haemophagocytic lymphohistiocytosis’ and subsequently found none. I had spelled it Hemophagocytic lymphohistiocytosis. To my surprise, when I re-did the query using the spelling with the ‘ae’, I found 169 reports.
These 169 are likely the real tip of a melting iceberg. VAERS is already under-reported and this syndrome goes mis-diagnosed a lot of the time.
Let me be clear here: this syndrome is rare and there are 169 reports in VAERS in the context of the COVID-19 shots.23 Think about that.
In the past 10 years, there have been 2 reports of HLH (4/100,000 AEs reported in 2019) in the context of all vaccines combined - both made in 2019 (FLU and MMR). In the context of the COVID-19 shots, since 2021, there are 169 total reports → 17/100,000 AEs.
Wait. There’s more.
The primary version of this syndrome most commonly affects very young children.
The onset of HLH occurs before the age of one year in approximately 70 percent of cases.4
The secondary version of this syndrome most commonly affects adults with a mean age of 50 years.
Secondary HLH presents in adults (mean age of approximately 50) in response to an acute illness trigger rather than an underlying genetic mutation. (Ref #1)
Notice, even with the low absolute counts, that the rate of HLH is highest in seniors. That’s atypical for both versions.
This is a syndrome highly-associated with Epstein-Barr Virus (EBV) and other viruses as triggers.
Secondary HLH also occurs rarely in immunodeficiency disorders such as severe combined immunodeficiency, DiGeorge syndrome, Wiskott–Aldrich syndrome, ataxia–telangiectasia, and dyskeratosis congenita);5 and infections caused by EBV, cytomegalovirus, HIV/AIDS, bacteria, protozoa, fungi and SARS-CoV-2.678
Secondary HLH may also result from iatrogenic causes such as bone marrow or other organ transplantations; chemotherapy; or therapy with immunosuppressing agents.9
…Or transfection technology inducing strong and prolonged immune activation of T cells and macrophages?
Some more characteristics of our 169:
The 169 reports of HLH have a 50:50 M:F ratio. 17% of the reports also contained reports of EBV infections., 7.7% also contained reports of HIV and 11.2% also contained CMV reports. 3% had in-tandem reports of general autoimmune disorders.
73% were hospitalized. 18% died. 61% were classified as ‘uncovered’.
That’s it for now. I will keep this updated. And sorry if it’s a bit scattered. I finished this up during a live Q&A session.
Just for kicks, it turns out that endotoxins up-regulate the gene coding for ferritin causing the concentration of ferritin to rise.10
Konkol S, Rai M. Lymphohistiocytosis. [Updated 2023 Mar 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557776/
Parikh SA, Kapoor P, Letendre L, Kumar S, Wolanskyj AP. Prognostic factors and outcomes of adults with hemophagocytic lymphohistiocytosis. Mayo Clin Proc. 2014 Apr;89(4):484-92
Allen CE, McClain KL. Pathophysiology and epidemiology of hemophagocytic lymphohistiocytosis. Hematology Am Soc Hematol Educ Program. 2015;2015:177-82
https://en.wikipedia.org/wiki/Hemophagocytic_lymphohistiocytosis
Bode SF, et al. (July 2015). "The syndrome of hemophagocytic lymphohistiocytosis in primary immunodeficiencies: implications for differential diagnosis and pathogenesis". Haematologica. 100 (7): 978–88. doi:10.3324/haematol.2014.121608
Mehta, Puja; McAuley, Daniel F.; Brown, Michael; Sanchez, Emilie; Tattersall, Rachel S.; Manson, Jessica J. (2020-03-28). "COVID-19: consider cytokine storm syndromes and immunosuppression". The Lancet. 395 (10229): 1033–1034. doi:10.1016/S0140-6736(20)30628-0
Fajgenbaum, David C.; June, Carl H. (2020-12-03). Longo, Dan L. (ed.). "Cytokine Storm". New England Journal of Medicine. 383 (23): 2255–2273. doi:10.1056/NEJMra2026131
Braga Neto, Manuel B.; Badley, Andrew D.; Parikh, Sameer A.; Graham, Rondell P.; Kamath, Patrick S. (2022-02-03). Solomon, Caren G. (ed.). "Calm before the Storm". New England Journal of Medicine. 386 (5): 479–485. doi:10.1056/NEJMcps2111163
Daver N, McClain K, Allen CE, Parikh SA, Otrock Z, Rojas-Hernandez C, Blechacz B, Wang S, Minkov M, Jordan MB, La Rosée P, Kantarjian HM (September 2017). "A consensus review on malignancy-associated hemophagocytic lymphohistiocytosis in adults". Cancer. 123 (17): 3229–3240. doi:10.1002/cncr.30826
Ong DS, Wang L, Zhu Y, Ho B, Ding JL (2005). "The response of ferritin to LPS and acute phase of Pseudomonas infection". Journal of Endotoxin Research. 11 (5): 267–80. doi:10.1179/096805105X58698
I know two people who are elderly who are being tested like pin cushions for odd blood problems... and yet fit this syndrome!!! But it is NOT being diagnosed in Toronto as such. Aspects fit other more common diagnoses that (mis) guide treatments, even when they aren’t working well.
WHAT medical practitioner or specialist should and DOES even know about this syndrome in someone NOT a baby?
Misdiagnoses of people over 65 in Canada, leading to fast multi system failure is just another reason to say, but they are elderly... not expected to live, they had... high blood pressure in one case, and arthritis in the other. Yet, they were energetic and mobile until booster shot 3/4.
Meantime, Canadian doctors are going missing in action. Boosted out of work, if not life. I am sorry for their dogmatic idiocy: their loss is also a human disaster. Meantime, the largest province in Canada, has made a theoretical $1.6 billion budget surplus in the last year by NOT delivering medical care that was budgeted. In-home seniors and mental health, (‘community’) services have been stopped (despite program announcements to the contrary).
You know who has the proper data? Big pharma can purchase detailed population medical and prescription data from the provincial government.
Academics have been corrupted by discovery dollars from the US military budget. Doctors are driven by the next $500/hour steady work doing the same old without learning or adapting (if they survive their own practice).
And people are dying from undiagnosed spikopathy.
Once world leaders in genuine health care (including prevention) against the commercialized American specialized biomedicine, Canadians have succumbed and, sadly suckered. Our government paid care follows American standards. Yet, Americans made this.
So how do we up the expertise, medical diagnosis of countermeasure countermeasures to deliver services that have some potential for practical humane benefit?
Our doctors consent are uninformed so promote iatrogenic harm.
We need to all take care.
Thank you for your great reporting.
I have ideas about what can be done to rally proper care. Let me know if you /anyone cares to collaborate.
Jessica, your output of important digs into these matters amazes me. You also make much of it reasonably easy for me to understand. Thanks you.