Can we be sure whether this process known as "positive selection" is really a "natural process" (such as might occur in a herd of mice living in a barn, or under a house)? Or are we referring to the results of "Gain of Function" experiments?
In the graph of "Haddock score", it looks like the change in Omicron spike protein is about 200 million years. Is that relative to mammalian DNA-based evolution, and how does that scale to viral evolution? Are we, literally, looking at 200 million years of evolution compressed into one?
If this sort of evolution could occur in mice, then why doesn't the virus similarly mutate in turbo-charged selective fashion in humans? And how could the virus adapt so well to mice, while simultaneously gaining ability to infect people?
"Where have I heard of Mus musculus being used before"? I've heard of such things as "humanized mice" (with human ACE-2) used in the Daszak labs. But this paper is talking about ordinary house mice, right? If someone were trying intentionally to make a highly contagious version of SARS-Cov2, wouldn't they use "humanized mice"?
Hi Jess. Thank you so much for your time, effort, and concern for your fellow humans. Are you saying that as is likely the case with the original virus, that Omnicron was likely cooked up in a lab?
They do but SARS-CoV does not bind very well in mice, hence the need to create ACE2-humanized mice lines. See this article:
"Because the mouse ACE2 does not bind efficiently to SARS-CoV or SARS-CoV-213, several ACE2-humanized mouse lines have been generated, and can be relevant to research related to the COVID-19 outbreak ...
In these models, the human ACE2 gene (hACE2) has been placed under control of a promoter of choice to induce expression in a specific tissue or cell type in mice (Fig. 3 and Table 4). These strains are readily susceptible to SARS-CoV-2 infection and would be invaluable for studies of the pathogenesis and antiviral therapies for COVID-19."
On Dr Richard Fleming's site he lists a paper that shows the spike protein crossed the blood/brain barrier in mice and all mice with the ACE2 receptor who received the spike protein died 2 weeks later not from covid, but of brain disease.
Amazing stuff. I am almost inspired to learn more. All this going on under our skin and we don't have to understand it. The wizards of biowarfare may be out of control.
i love you Jessica. Keep fighting the fight
I suppose that it's time someone said curiouser and curiouser again.
This guy went down the rabbit hole several weeks ago.
https://igorchudov.substack.com/p/omicron-as-a-bioweapon-thoughts-and
Vaccines. Just searching now to see if it was Pfizer or Astro Zeneca. I guess the next variant will be from monkeys right?
Can we be sure whether this process known as "positive selection" is really a "natural process" (such as might occur in a herd of mice living in a barn, or under a house)? Or are we referring to the results of "Gain of Function" experiments?
In the graph of "Haddock score", it looks like the change in Omicron spike protein is about 200 million years. Is that relative to mammalian DNA-based evolution, and how does that scale to viral evolution? Are we, literally, looking at 200 million years of evolution compressed into one?
If this sort of evolution could occur in mice, then why doesn't the virus similarly mutate in turbo-charged selective fashion in humans? And how could the virus adapt so well to mice, while simultaneously gaining ability to infect people?
"Where have I heard of Mus musculus being used before"? I've heard of such things as "humanized mice" (with human ACE-2) used in the Daszak labs. But this paper is talking about ordinary house mice, right? If someone were trying intentionally to make a highly contagious version of SARS-Cov2, wouldn't they use "humanized mice"?
and this was a.... lab mouse? The virus "jumped"? Mebbe it was "pushed"?
Hi Jess. Thank you so much for your time, effort, and concern for your fellow humans. Are you saying that as is likely the case with the original virus, that Omnicron was likely cooked up in a lab?
So, it is my understanding that mice do not have an ACE2 receptor unless given one - by lab researchers. Correct? So this was another lab event.
They do but SARS-CoV does not bind very well in mice, hence the need to create ACE2-humanized mice lines. See this article:
"Because the mouse ACE2 does not bind efficiently to SARS-CoV or SARS-CoV-213, several ACE2-humanized mouse lines have been generated, and can be relevant to research related to the COVID-19 outbreak ...
In these models, the human ACE2 gene (hACE2) has been placed under control of a promoter of choice to induce expression in a specific tissue or cell type in mice (Fig. 3 and Table 4). These strains are readily susceptible to SARS-CoV-2 infection and would be invaluable for studies of the pathogenesis and antiviral therapies for COVID-19."
https://www.nature.com/articles/s41467-020-18880-0
On Dr Richard Fleming's site he lists a paper that shows the spike protein crossed the blood/brain barrier in mice and all mice with the ACE2 receptor who received the spike protein died 2 weeks later not from covid, but of brain disease.
Were those mice wearing lab coats?
Here's another excellent article (from 1-02-22) on this same subject, which was a tad easier for me to grasp:
https://bprice.substack.com/p/lab-leak-20
Sure sounds like Omicron originated from a lab, where SARS-CoV-2 was modified using humanized mice...
Yes, another lab one.
omfg, they both got hit by a car, but all cases are adjudicated. thx, never would have seen this clip. OMFG, these people!
Ms. Jessica have you seen this post by @Parsifaler Walter M Chestnut - I follow his research
https://twitter.com/Parsifaler/status/1480534969013440515?s=20
He is aligning the spike protein to be a cancer producer.
Amazing stuff. I am almost inspired to learn more. All this going on under our skin and we don't have to understand it. The wizards of biowarfare may be out of control.
Human to Mouse to Human; natural or lab that is the question. Keep up the great work Jessica!