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Thank you Ms. Rose. I must confess that this is over my head, so any comment from me would be the peanut gallery.

I can safely say however, that we are blessed to have you on the case and you and your peers will get to the bottom of it.

I will be following along and continue to learn from your work.

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If most injections are also ~30 days after manufacture, product expiration would be redundant in terms of the resulting AE plot and real world impact. So we would need the injections by date after manufacture plot to see if there are any people actually being protected by hypothetical product expiry.

On the other hand if manufacturer, cold chain, and dosage inconsistency determine functioning mRNA payload, it’s pure Russian Roulette. I think Bhargava recently mentioned LNP bubble size as a potential payload randomizer. But VAERS is full of dilution/injection errors, including for the 5-11 product.

But the Röltgen, K. et al. paper suggests consistent payload at least in the sense that no one is getting “no spike.” 96% of recipients have detectable spike in plasma on day 1-2 and 63% at day 7. Similar results for mRNA and spike in the germ centers, with lots of hits still on day 37 post 2nd-dose and few after. So it seems like everyone who gets the shot is getting a lot of intact mRNA. The variability is in how long it sticks around.

Not discussed much, the paper also finds aberrantly cross-protective antibody enrichment against the RBD vs non-mRNA shots or infection with “Wuhan” strain (fig 4), as in binding against variants / binding against Wuhan ratio was much more even for Pfizer recipients. Even though the mRNA supposedly codes for the Wuhan spike. This suggests there is variability in the output, perhaps lots of mutant spike production, though it could also be some weird influence on APC epitope selection, maybe from the pseudouridine, maybe from the “slow release” factor of mRNA continuing to become available to APCs for weeks after dosage. Malone says the results suggest the mRNA is lingering in the immune cells but I think it reflects delayed capture from transfected non-immune cells.

Perhaps someone should have tested how these things work in a lab or something.

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What ever happened to the “ultra cold” storage requirement? I remember ultra cold being a requirement when the Vax was initially launched…then the refrigeration requirement was relaxed and now it’s stored in freezers (or refrigerators) at Walmart and CVS!!!! Did Pfizer or CDC officials ever say? Just curious.

I think about this almost ever day… “why has my jabbed extended family been spared while others experience AEs?”

Great article and topic though.

Thanks Jessica.

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"Scientifically", this should bring to an end mRNA treatments altogether, at least until BigPharma does at least another 5-10 years of R&D, preferably overseen by a panel of experts with nothing to gain or lose - a small group of Heinlein's "Fair Witnesses". (Stranger in a Strange Land) Names you mention here would surely qualify.

But according to this article from 2017,

https://endpts.com/pharmas-broken-business-model-an-industry-on-the-brink-of-terminal-decline/

BgPharma is already sunk:

"What we have here is an industry that is entering a vicious cycle of negative growth and terminal decline as its fundamental business model has run out of steam by the Law of Diminishing Returns: Diminishing R&D productivity and return on investment leads to diminishing growth in sales."

But of course Marcia Angell predicted this too, in her book and a New York Review of Books article back in 2004. For an excerpt see

https://peterwebster.substack.com/p/pandemic-the-next-big-thing

She writes,

"Even worse is the fact that there are very few drugs in the pipeline ready to take the place of blockbusters going off patent. In fact, that is the biggest problem facing the industry today, and its darkest secret. All the public relations about innovation is meant to obscure precisely this fact. The stream of new drugs has slowed to a trickle, and few of them are innovative in any sense of that word... For the first time, in just a few short years, the gigantic pharmaceutical industry is finding itself in serious difficulty. It is facing, as one industry spokesman put it, “a perfect storm.” Nevertheless, the industry keeps promising a bright new day. It bases its reassurances on the notion that the mapping of the human genome and the accompanying burst in genetic research will yield a cornucopia of important new drugs." [You guessed it.]

Seems to me that mRNA technology for SARS-CoV-2 was supposed to be the life jacket to halt the sinking, with further applications of miracle mRNA treatments to follow for everything you (or they) can name. A brand new Titanic to put BigPharma on course again. If you speak French, check out this puff-piece on the French-German "intellectual" TV channel, ARTE:

L’ARN messager : une révolution médicale

https://www.arte.tv/fr/videos/103509-000-A/l-arn-messager-une-revolution-medicale/

The whole mess even raises the horrible thought that "the virus"...

SARS-CoV-2 was concocted in a laboratory, and intentionally released for the express purpose of selling the mRNA injections that were supposed to control the plandemic. But additionally, and perhaps primarily, the introduction of mRNA technology for SARS-CoV-2 was supposed to be the first example of a great new medical miracle that would have applications in all areas of disease and health.

https://peterwebster.substack.com/p/re-bigpharma-negative-return

To suppose that the appearance of "the virus" was a coincidental (accidental) event and BigPharma simply jumped in to help out in a serious situation,

Is about the same as insisting a few Arabs who couldn't fly planes just coincidentally brought about the Pearl Harbor Event needed by the Bush-era neocons to then perpetrate the horrors they will be eternally infamous for.

On another matter,

Bourla's eyes go in weird directions, anyone else notice that? If that indicates something about the central neurology behind...

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This raises the issue again of variation in AEs between vaccine lots, doesn't it?

Also, concerns about integrity of mRNA and translation products introduces the potential for an increased number of cross reactions with various tissues. It worries me that a lot of the AEs we are seeing look to be autoimmune in nature. Perhaps the variability in mRNA and translated protein products is a reason. We may be dealing, in other words, with multiple spike forms with enough variation to drive a humoral or cell mediated attack on any number of host antigens. Am I on track here? I don't know. Add in the pharmacokinetics which were never really described and the fact that mRNAase probably varies a lot between people, and who knows what you get with the shot? It's a crap shoot.

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We are ruled by compromised perverts!!!

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Not sure if this would be meaningful or not but given we're talking about mRNA degredation - It looks like back in December, the FDA authorized an extension of the expiration dates for BioNtech's product from 6 to 9 months. As far as I can tell from this one release - the extension was specific for BioNtech's product containing the Tris Buffer. They also granted at least 2 authorizations for the extension of the shelf life for Janssen's product. The first was in June 2021 for an extension from 3 to 4.5 months and the second was a month later in July - from 4.5 months to 6 months.

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I am not a scientist, but wrote an article in November speculating about the possibility of mRNA from the vaccines becoming damaged or oxidized, which could gunk up ribosomes. So is this possible, especially in conjunction with degraded LNPs? https://wholistic.substack.com/p/mrna-damage-cellular-function

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I am wondering whether the Pfizer shots use sr-mRNA, as in self-replicating mRNA. I saw once, in a document table listing various vaccines, that a version of the Pfizer shot was sr. That would help to explain evidence of long lasting spike protiens.

What do you think?

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For me the keyword is integrity. Integrity is defined as incorruptability. Obviously "corrupted" RNA will produce unpredictable results, to the good or the bad. This raises the question of whether there are really 30 units of RNA in every jab.

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Hi Jessica,

I believe you may of covered this before regarding shingles coming back due to Covid jabs. The UK has just started an advertising campaign saying it’s normal for this to come back in older people as their immune system weakens! I can only assume that we are seeing large scale numbers of people getting shingles for them to have to start putting out adverts about it. The website they have created and publicise during the advert is: https://www.understandingshingles.co.uk/

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I just got a job in a pharmacy. No vax and no masks, happily. But they keep the jab juice out at room temperature all day! My experience with RNA is it’s extremely fragile when warm. Guess the lnp coating stabilizes the crap.

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Very interesting, but how do you get the product manufacturing date? Is it encoded in the vax lot number or do you have a separate document for that? I can't see anything on VAERS request form about manufacturing date...

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LOVE the shoe analogy & your considerations toward translating field nomenclature/'lingo' various sciences' concepts/ as you move thru this update.Wow-what an interesting idea/variables to check out!

Thoughts:

1) Pharm degradation sometimes makes for harmful effects doesn't it-eg sunscreen (blanking on po meds, but as RN giving meds Xyrs, know there are some).Wondering: if pieces of Virus can set off more cytokine storm--is it possible degraded mRNA might, too--or are you thinking b/c the protien-line-formation-of-these NYC-Rockettes's has been disconnected & they're dancing solo or in other # of linked formations--that means they've lost their kick/moxie?

2) If this vac still has time limitations eg 2hr outside fridge, use w/in 5 days, etc-sounds like they're not saying how that effects contents--other than, might not be useable beyond time b/c degrades--but is limit b/c will be ineffective or degradation would be harmful?

Watched couple how to prepare/admin.it youtube videos--'Do Not Shake/will cause frothing.' Might just be a time efficiency thing so don't have to flick air bubbles out for an hour!-but maybe it's that FRAGILE--supposed to, 'Invert it 10xs GENTLY in order to mix it' (twice during constituting process)

So makes me think, if the increased time between manufacture & injection date might increase chance of mishandling a fragile product (one video noted minimize exposure to light, too), your idea makes sense to me.

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Wow, what an interesting observation, looking at AE's compared to manufacturing date. Empty LPNs vs. saline and the effects of truncated mRNA and the relationship to prion disease. Thinking back to one of your prior posts on prion disease, this is a very interesting question that should have been addressed by the pharmaceutical companies before the mass rollouts turning us all into their guinea pigs. Thank you for all that you do!

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Also that part,"..considering that the current...criteria allows for up to 50% fragmented species" reminds me of old dangerous manufacturing limits of only 3 rodent body parts/x amt sausage meat" & Image: oh yhea, like 50% of tablets in a med bottle are crushed/in various size little pieces--now figure out how to administer this am's dose accurately🧐

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