Research on CD147 may be very helpful in the long run. I am a retired physician and am aware of studies showing that aspirin will slow down progression of emphysema. Perhaps the stimulation of fibroblasts is due to local micro-clotting attracting fibroblasts by way of signals from platelets aggregating at these sites.
So my first question is: Does aspirin, Plavix, heparin, or other anti-platelet/anticoagulant-class medications used in hospitalized COVID-19 patients reduce the chance of pulmonary fibrosis?
My second question is: Do the new endothelial cell protective agents such as Flavicin and Salifen have benefit in such patients?
Lastly, there is a relatively inexpensive medication/(extract) named Pynogenol used in preventing recurrent venous thrombosis in patients with lower extremity venous insufficiency and more to the point, good studies showing it is protective in diabetic retinal micro-vascular disease. If I were a patient suffering from progressive COVID-induced pulmonary fibrosis, I would certainly look into these types of options.
I believe many ppl are experiencing heparin/blood thinner resistance now… I’ve read about it and experienced it in the OR. They repeatedly give heparin throughout procedure but fail to obtain therapeutic dosing. Not sure how often this is happening but I’m aware and have seen it enough to be very concerned.
I have read reports where Funeral Home personnel are having difficulties in the embalming process due to the presence long and unusual blood clots of a new and different nature in the recently dead, that they had not encountered before.
My question about the pulmonary fibrosis is: how long might it take to manifest?
Will it manifest more so in someone who already has interstitial lung disease with fibrosis?
My husband, a first responder at 911 now has ILD. His disease was slow moving but over one month he tanked with water in his lungs and couldn't breathe. Now he is on oxygen and can barely get through a shower without being completely exhausted. he was double jabbed in March 2021. no booster.
I am sorry your family is suffering and it is even more tragic that a 911 responder is paying a price for his heroism.
I presume that your husband is under the care of a pulmonologist. You can ask the pulmonologist if he or she believes your husband's ILD dramatically worsened shortly after the vaccine, or if the worsening disease course is due to the original cause. If due to the underlying lung inflammation from exposure to nasty particulates inhaled during his efforts to save the lives of 911 victims, then I would recommend asking his care givers about a traditional Chinese herbal medication used successfully in clinical trials against Systemic Sclerosis auto-immune ILD. That medicine is called: Tripterygium wilfordii Hook F and you can read about it in the medical literature. Ask your physician about compassionate use of this medicine.
😥 I’m so sorry. An excellent supplement for lungs is NAC… but I’m not a MD or a specialist in lungs. Pierre Kory is treating shot injured patients remotely. Could reach out to his team?
We already have him taking NAC. We are going to start him on some chinese herb/tinctures made here in OR.
His crash happened 1.5 years after the jabbed. couldn't be the jab, or could it. PS several of his team members have either the same disease diagnosed or a bad cough undiagnosed.
Oh it could most definitely be… my sister has had inflammation on side she got hers and 1.5yrs later she had an ovary and appendix removed on that side!
We know from animal studies that the lipid nano-particles carrying the spike protein of the vaccine preferentially accumulate in the ovaries at a 4:1 ratio.
Stopping pulmonary fibrosis is certainly worthwhile. In hepatic fibrosis there is regeneration of tissue if the cause is removed- the structure may not be perfect, but the function is pretty good.
Reversal of pulmonary fibrosis is usually not seen; Kaplan-Meier nomograms for pulmonary function with age show a consistent decline. For instance, quitting smoking does not restore the lung function to the baseline for age, but the slope of the decline may become parallel to the "normal" for age. As in myocarditis, the damage from pulmonary fibrosis should be seen as permanent.
It would be good to put the mice through another study comparing proper early treatment to untreated Covid infection to mRNA injection.
Spike protein is a nasty devil. A new preprint that just showed up today speaks to the fact that spike induces hemagluttination, and that IVM both stops this, and even reverses it after the fact.
Title: SARS-CoV-2 Spike Protein Induces Hemagglutination: Implications for COVID-19 Morbidities and Therapeutics and for Vaccine Adverse Effects
Conclusions: Spike protein from four lineages of SARS-CoV-2 induced HA in human RBCs, which supports other indications that spike protein-induced RBC clumping, as well as viral attachments to other blood cells and endothelial cells, may be key to the morbidities of COVID-19. IVM, a macrocyclic lactone indicated to bind strongly to multiple glycan sites on SARS-CoV-2 spike protein, blocked HA when added to RBCs prior to spike protein and reversed HA when added afterwards......
The paper also mentions CD147; "For endothelial cells of blood vessel linings, for example, the disparity between 28,000 SA-tipped CD147 receptors and 175 ACE2 receptors per cell21 51 provides a supporting indication of the role of glycans in widespread endothelial damage reported in COVID-19 patients" Note that SA = terminal sialic acid moieties.
Research on CD147 may be very helpful in the long run. I am a retired physician and am aware of studies showing that aspirin will slow down progression of emphysema. Perhaps the stimulation of fibroblasts is due to local micro-clotting attracting fibroblasts by way of signals from platelets aggregating at these sites.
So my first question is: Does aspirin, Plavix, heparin, or other anti-platelet/anticoagulant-class medications used in hospitalized COVID-19 patients reduce the chance of pulmonary fibrosis?
My second question is: Do the new endothelial cell protective agents such as Flavicin and Salifen have benefit in such patients?
Lastly, there is a relatively inexpensive medication/(extract) named Pynogenol used in preventing recurrent venous thrombosis in patients with lower extremity venous insufficiency and more to the point, good studies showing it is protective in diabetic retinal micro-vascular disease. If I were a patient suffering from progressive COVID-induced pulmonary fibrosis, I would certainly look into these types of options.
I believe many ppl are experiencing heparin/blood thinner resistance now… I’ve read about it and experienced it in the OR. They repeatedly give heparin throughout procedure but fail to obtain therapeutic dosing. Not sure how often this is happening but I’m aware and have seen it enough to be very concerned.
I have read reports where Funeral Home personnel are having difficulties in the embalming process due to the presence long and unusual blood clots of a new and different nature in the recently dead, that they had not encountered before.
My question about the pulmonary fibrosis is: how long might it take to manifest?
Will it manifest more so in someone who already has interstitial lung disease with fibrosis?
My husband, a first responder at 911 now has ILD. His disease was slow moving but over one month he tanked with water in his lungs and couldn't breathe. Now he is on oxygen and can barely get through a shower without being completely exhausted. he was double jabbed in March 2021. no booster.
I am sorry your family is suffering and it is even more tragic that a 911 responder is paying a price for his heroism.
I presume that your husband is under the care of a pulmonologist. You can ask the pulmonologist if he or she believes your husband's ILD dramatically worsened shortly after the vaccine, or if the worsening disease course is due to the original cause. If due to the underlying lung inflammation from exposure to nasty particulates inhaled during his efforts to save the lives of 911 victims, then I would recommend asking his care givers about a traditional Chinese herbal medication used successfully in clinical trials against Systemic Sclerosis auto-immune ILD. That medicine is called: Tripterygium wilfordii Hook F and you can read about it in the medical literature. Ask your physician about compassionate use of this medicine.
😥 I’m so sorry. An excellent supplement for lungs is NAC… but I’m not a MD or a specialist in lungs. Pierre Kory is treating shot injured patients remotely. Could reach out to his team?
We already have him taking NAC. We are going to start him on some chinese herb/tinctures made here in OR.
His crash happened 1.5 years after the jabbed. couldn't be the jab, or could it. PS several of his team members have either the same disease diagnosed or a bad cough undiagnosed.
Oh it could most definitely be… my sister has had inflammation on side she got hers and 1.5yrs later she had an ovary and appendix removed on that side!
We know from animal studies that the lipid nano-particles carrying the spike protein of the vaccine preferentially accumulate in the ovaries at a 4:1 ratio.
Stopping pulmonary fibrosis is certainly worthwhile. In hepatic fibrosis there is regeneration of tissue if the cause is removed- the structure may not be perfect, but the function is pretty good.
Reversal of pulmonary fibrosis is usually not seen; Kaplan-Meier nomograms for pulmonary function with age show a consistent decline. For instance, quitting smoking does not restore the lung function to the baseline for age, but the slope of the decline may become parallel to the "normal" for age. As in myocarditis, the damage from pulmonary fibrosis should be seen as permanent.
It would be good to put the mice through another study comparing proper early treatment to untreated Covid infection to mRNA injection.
Conveyed with excellence. Big Thank You / Kudos.
Damn that spike protein.
Spike protein is a nasty devil. A new preprint that just showed up today speaks to the fact that spike induces hemagluttination, and that IVM both stops this, and even reverses it after the fact.
https://www.biorxiv.org/content/10.1101/2022.11.24.517882v1.full.pdf+html
Title: SARS-CoV-2 Spike Protein Induces Hemagglutination: Implications for COVID-19 Morbidities and Therapeutics and for Vaccine Adverse Effects
Conclusions: Spike protein from four lineages of SARS-CoV-2 induced HA in human RBCs, which supports other indications that spike protein-induced RBC clumping, as well as viral attachments to other blood cells and endothelial cells, may be key to the morbidities of COVID-19. IVM, a macrocyclic lactone indicated to bind strongly to multiple glycan sites on SARS-CoV-2 spike protein, blocked HA when added to RBCs prior to spike protein and reversed HA when added afterwards......
The paper also mentions CD147; "For endothelial cells of blood vessel linings, for example, the disparity between 28,000 SA-tipped CD147 receptors and 175 ACE2 receptors per cell21 51 provides a supporting indication of the role of glycans in widespread endothelial damage reported in COVID-19 patients" Note that SA = terminal sialic acid moieties.