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philipat's avatar

I find myself increasingly drawn to the issue of mRNA integrity and, specifically, the temperature requirements for the supply chain. This is an aspect which I don't think has been adequately looked at.

Even in the US and Europe the ability to transport, store and deliver products at -70 degrees is patchy at best. In ROW, non-existent. As a side issue, even if stored correctly through to the point of delivery, were there adequate storage facilities at the point of delivery and were adequate instructions available as to how the product should be taken from -70 degrees down to injection temperateure and how long the vials can be kept under normal refrigeration? I suspect there are a LOT of grey areas here!

Setting aside for a moment the issue of efficacy, perhaps the good news is that degraded RNA cannot do the same harm. At the extreme,, the issue here becomes perhaps the batches that have been reported to cause many of the AEs were NOT, in fact, the "bad" batches, but actually the "good" batches which had been correctly temperature-controlled throughout!!

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Air Lift Underground's avatar

It stands to reason that degraded product is less dangerous, especially for acute, serious reactions, the kind that will send a signal to VAERS. What's left is the pseudo-u and NLP's, and these may certainly be immunosuppressive, but you aren't going to get spike-related syndromes without much spike.

There are way too many people walking around who not only have been fine, but everyone they know is, as well. This sometimes applies even to people who are aware of the dangers, but are bewildered that it hasn't landed in their circle of familiarity. This can really only be explained by a systemic effect at the local level; i.e., lax protocols for handling and storage, or a deliberate shipment of inactive product.

What would you do, if you had a runaway train of adverse reactions and no longer cared as much about efficacy as keeping the warp core from melting down? A change in protocols would be the quick fix.

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