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Robin Whittle's avatar

MISC and Kawasaki disease are diagnoses for essentially the same hyper-inflammatory (indiscriminate cell destruction by immune cells such as eosinophils, the suicide bombers of the immune system) disorder which especially affects the vasculature. Kawasaki disease is more often diagnosed in infants and children while MISC is typically diagnosed in older children, adolescents and young adults.

Stagi et al. 2015 "Severe vitamin D deficiency in patients with Kawasaki disease: a potential role in the risk to develop heart vascular abnormalities?" https://Clinical Rheumatology volume 35, pages 1865–1872 (2015) link.springer.com/article/10.1007/s10067-015-2970-6 (Paywalled) https://sci-hub.se/10.1007/s10067-015-2970-6 found that KD patients had even lower 25-hydroxyvitamin D levels than of ordinary children. While a little of this may be attributed to 25-hydroxyvitamin D being consumed during the illness, this is a brief period and the primary cause of the low 25-hydroxyvitamin D would be it being low to begin with, which means that very low 25-hydroxyvitamin D greatly raises the risk of Kawasaki disease - and so, MISC.

"The patients were 21 girls and 58 boys, average age 5.8 years. Their average 25(OH)D levels were 9.2ng/ml (23 nmol/L), while age-matched controls averaged 23.3 ng/mL (58 nmol/L). The average 25(OH)D level of the children who developed coronary artery abnormalities was just 4.9ng/ml (12.3 nmol/L)."

See discussion and further research at: https://vitamindstopscovid.info/00-evi/#4.5.

If the medical profession and immunologists were as interested in nutrition as they should be, news of this research would have spread like wildfire and within a year or two pretty much every doctor, nurse and immunologist would be aware of it, and so of the need for proper vitamin D3 supplementation to attain (it is hydroxylated primarily in the liver) much higher 25-hydroxyvitamin D levels.

There are hundreds of disease conditions where the same is true, not least sepsis and COVID-19. Even today, most medical professionals - and many in the health freedom movement - do not yet appreciate that proper vitamin D3 supplementation is necessary for almost everyone, since this is the only safe, practical way of attaining the 50 ng/mL (125 nmol/L = 1 part in 20,000,000 by mass) circulating 25-hydroxyvitamin D our immune systems need to function properly, all year round. There's very little vitamin D3 in food and, while UV-B exposure of ideally white skin can produce plenty of it, this is not available all year round far from the equator - and it always damages DNA and so raise the risk of skin cancer.

No matter what food we eat or lifestyle choices we make (except for high levels of ultraviolet B exposure of ideally white skin), the only way we can attain sufficient 25-hydroxyvitamin D is by supplementing proper amounts of vitamin D3 (or, in principle 25-hydroxyvitamin D) according to body weight and obesity status. The one exception is infants who are substantially breast fed by 25-hydroxyvitamin D replete mothers. Such breast milk contains both vitamin D3 and 25-hydroxyvitamin D (Tsugawa et al. 2021 https:// www.mdpi.com/2072-6643/13/2/573), the latter being more important since it is absorbed directly into the infant's circulation, while only (very approximately) 1/4 of ingested vitamin D3 is hydroxylated in the liver to circulating 25-hydroxyvitamin D.

Neither vitamin D3 cholecalciferol nor 25-hydroxyvitamin D calcifediol, made from vitamin D3, primarily in the liver) are hormones.

Please see the research cited and discussed at: https:// vitamindstopscovid.info/00-evi/. This begins with recommendations from New Jersey based Professor of Medicine, Sunil Wimalawansa on the average daily supplemental intake quantities of vitamin D3 which will attain least 50 ng/mL circulating 25-hydroxyvitamin D, over several months, without the need for blood tests or medical monitoring:

70 to 90 IU / kg body weight for those not suffering from obesity (BMI < 30).

100 to 130 IU / kg body weight for obesity I & II (BMI 30 to 39).

140 to 180 IU / kg body weight for obesity III (BMI > 39).

This is because obesity reduces the rate of hydroxylation in the liver and because the resultant 25-hydroxyvitamin D (and probably vitamin D3 itself) is sequestered in the excess adipose tissue: https://5nn.info/temp/250hd-obesity/.

For 70 kg (154 lb) body weight without obesity, this is about 0.125 milligrams (125 micrograms 5000 IU) a day. This takes several months to attain the desired > 50 ng/mL circulating 25-hydroxyvitamin D. This is 8 or more times what most governments recommend. "5000 IU" a day sounds like a lot, but it is a gram every 22 years - and pharma-grade vitamin D costs about USD$2.50 a gram ex-factory.

These recommendations are included in a recent article with another professor of medicine Scott T. Weiss and professor of pediatrics Bruce W. Hollis: https:// www.mdpi.com/2072-6643/16/22/3969. All three have been researching vitamin D for decades.

A fully functional immune system protects against cancer, autism, many chronic conditions such as auto-immune inflammatory diseases, preeclampsia, pre-term birth, sepsis and the later development of autism, ADHD, intellectual disability and schizophrenia in children and against neurodegeneration AKA dementia..

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Brandon is not your bro's avatar

What was it, avarice , depopulation or hate for the human race ? It was NOT ignorance.

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