VAERS reports contradict claim of no AEs in frameshifting context
Follow-up on the recent Nature paper by Mulroney et al.
“All of the harms from the COVID-19 injectable products were predictable, and preventable.”
Jessica Rose, PhD
A Nature publication by Mulroney et al. entitled N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting [1] was published on December 6, 2023. The authors showed that N1-methylpseudouridine affects the fidelity of mRNA translation via ribosome stalling resulting in the production multiple, unique and potentially aberrant proteins by frameshifting. Wiseman et al. subsequently penned a comment entitled Ribosomal frameshifting and misreading of mRNA in COVID-19 vaccines produces “off-target”proteins and immune responses eliciting safety concerns: Comment on UK study by Mulroney et al. to address concerns associated with these findings. [2]
The authors claim that slippery sequences: long runs of N1-methylpseudoridines, induce frameshifting whereby ribosomes slip or skip over these sequences to shift the reading frame to result in entirely different protein production. [3] According to their findings, this happened approximately 8% of the time. If we contextualize this finding to the in vivo human setting, the numbers of aberrant proteins that might be being produced is staggering.
I will target one phrase in the paper to convey full understanding of my concerns pertaining to adverse events in the context of aberrant protein production. The authors write:
Although there are no adverse outcomes reported from mistranslation of mRNA-based SARS-CoV-2 vaccines in humans, these data highlight potential off-target effects for future mRNA-based therapeutics and demonstrate the requirement for sequence optimization.
Where is the evidence to support the claim that there are no adverse event outcomes in this context? According to a query of the MedDRA code “Autoimmune disorder” in the Vaccine Adverse Events Reporting System (VAERS), there is an 803% increase in reporting rate per million doses administered when comparing Influenza vaccines administered from 2018 through 2020 to COVID-19 modified mRNA injections administered from 2021 through 2023. It is worth noting that the reports exclude individuals with a history of an autoimmune disorder.
Autoimmune disorders could arise in the context of off-target protein production. [4] For example, if an immune response was generated against off-target proteins that share sequence homology to self proteins, then these mediators could very well be self-reactive. [5, 6, 7, 8]
As a proof of concept, Hepatitis B virus (HBV) vaccine-induced autoimmunity has been demonstrated in the context of demyelinating autoimmune diseases such a Multiple sclerosis. [9] Multiple sclerosis (MS) is an autoimmune disease whereby brain and spinal cord nerve cell insulation is damaged by self-reacting immune mediators. [10]
It is noteworthy that according to a query of the MedDRA code “Multiple sclerosis” in the VAERS database, there is a 890% increase in reporting rate per million doses, again when comparing Influenza vaccines administered from 2018 through 2020 to COVID-19 modified mRNA injections administered from 2021 through 2023. It is worth noting that the reports exclude individuals with a history of multiple sclerosis.
The increase in reporting rates of autoimmune disorders and MS in the context of the modified mRNA COVID-19 injectable products is obvious so the question is: Are these increases due to aberrant protein production?
The fact that off-target proteins are being produced is very concerning. Molecular mimicry hotspots in the spike protein have already been discovered with autoimmune potential in the context of thrombocytopenia. [11] A TQLPP motif in the spike protein shares similar antibody binding properties to the human protein thrombopoietin. Antibodies cross-reacting with thrombopoietin may induce thrombocytopenia, a condition observed in COVID-19 patients. [12]
In light of these new findings by Mulroney el al., it is clear that these products require recall and investigation. Any idea of ‘future mRNA-based therapeutics’ should be deferred indefinitely.
It is indeed curious that the manufacturers had every opportunity and resource to assess the dangers of off-target protein production for subsequent illumination and potential amelioration of potential AEs, including autoimmunity, prior to injecting billions of people, but did not exploit these opportunities. Clinical trials for these products should have spanned many generations to ensure the actual safety of these products.
[1] Mulroney, T.E., Pöyry, T., Yam-Puc, J.C. et al. N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting. Nature (2023). https://doi.org/10.1038/s41586-023-06800-3
[2] Wiseman, D. M., PhD, Gutschi, L. M., Speicher, D. J., Rose, J., & McKernan, K. (2023, December 6). Ribosomal frameshifting and misreading of mRNA in COVID-19 vaccines produces “off-target” proteins and immune responses eliciting safety concerns: Comment on UK study by Mulroney et al. https://doi.org/10.31219/osf.io/nt8jh
[3] Morais P, Adachi H, Yu YT. The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines. Front Cell Dev Biol. 2021 Nov 4;9:789427. doi: 10.3389/fcell.2021.789427. PMID: 34805188; PMCID: PMC8600071
[4] Vojdani A, Vojdani E, Kharrazian D. Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune Diseases. Front Immunol. 2021 Jan 19;11:617089. doi: 10.3389/fimmu.2020.617089. PMID: 33584709; PMCID: PMC7873987
[5] Kanduc D, Shoenfeld Y. Molecular mimicry between SARS-CoV-2 spike glycoprotein and mammalian proteomes: implication for the vaccine. Immunol Res (2020) 68(5):310–3. 10.1007/s12026-020-09152-6
[6] Lyons-Weiler J. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. J Transl Autoimmun (2020) 3:100051. 10.1016/j.jtauto.2020.100051
[7] Kanduc D, Shoenfeld Y. Molecular mimicry between SARS-CoV-2 spike glycoprotein and mammalian proteomes: implication for the vaccine. Immunol Res (2020) 68(5):310–3. 10.1007/s12026-020-09152-6
[8] Kanduc D. Peptide cross-reactivity: the original sin of vaccines. Front Biosci (2012) 4:1393–401. 10.2741/s341
[9] Segal Y, Shoenfeld Y. Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction. Cell Mol Immunol (2018) 15(6):586–94. 10.1038/cmi.2017.151
[10] https://www.ninds.nih.gov/health-information/disorders/multiple-sclerosis#toc-what-is-multiple-sclerosis-
[11] Nunez-Castilla, J.; Stebliankin, V.; Baral, P.; Balbin, C.A.; Sobhan, M.; Cickovski, T.; Mondal, A.M.; Narasimhan, G.; Chapagain, P.; Mathee, K.; et al. Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human Proteins. Viruses 2022, 14, 1415. https://doi.org/10.3390/v14071415
[12] Bhattacharjee S, Banerjee M. Immune Thrombocytopenia Secondary to COVID-19: a Systematic Review. SN Compr Clin Med. 2020;2(11):2048-2058. doi: 10.1007/s42399-020-00521-8. Epub 2020 Sep 19. PMID: 32984764; PMCID: PMC7501509
It’s very difficult for me to imagine that the drug pushers didn’t know the results the shots would have. Every indication is that the harms were intentional. “Conspiracy theorists” have been saying so since before there was ‘proof’ but thanks to scientists such as yourself digging in, we can now see the proof, and we are no longer believing or saying conspiratorial things.
I don’t quite understand the process.
We were told that the quantity of the original covid virus after the infection was so small that it could not be extracted directly from the body to confirm its existence. That’s why a PCR test was needed - that artificially multiplied what was in a sample taken from the suspect. When the multiplication process produced enough copies of a specific virus part, the diagnosis was made: “Infected”.
Nobody ever published a uniform reference to confirm the presence of the virus in the sample (not in a living person from whom the sample was taken). Labs used varying multiplications, with no scientific basis - because such reference basis was never published. This situation continues until now. One lab may use 20 multiplication cycles, while another will go up to 40. Or, in the same lab, one process will use 20 cycles, while another will exceed 35. No reference basis, no need to conform to anything.
That minuscule quantity of the original virus was not enough to detect it in a live person or, more often than not, to make this person sick. In the light of the conventional medicine before 2020, this condition would be called “healthy”.
However, we were told - under the same circumstances - that this undetectable quantity was sufficient to make that person sick and to make this person a walking threat to others. The population was divided into two groups: sick (those who were tested) and “sick, but not knowing that they are sick” (those who didn’t take the test). The new medicine was born, erasing everything all medical professionals were taught and practiced before 2020.
To get out of this crisis, an artificial biological substance was produced which makes the body create the most dangerous portion of this virus inside the organism, even if it was never there. To make it possible, original functions of cells of human body were programmed to be switched off. Cells had to stop doing what they were doing (we call it “life”) and start producing the most deadly part of this virus. As a result, any sample taken from the person injected with this artificial product may be called “sick”, because the body autonomously produces the signature part of the virus - its deadly payload.
The cell that does not do what it is supposed to do is immediately identified by the defense systems of the body and marked “destroy”. It has to be this way - the cell went rogue, does not support the life process of the body, and the body in its infinite wisdom has to get rid of it. The defense mechanisms of the body attack the defective cell and eliminate it from the body. The result is broadly called “autoimmune disorder”.
We were never told which cells of the body will be activated by the artificial injected substance, or for how long, or how this activation process can be turned off. Theoretically, as an example, if all cells of the heart are activated to produce the virus signature, your body will attack and try to destroy all the cells of your own heart. Or lungs. Or liver. Or brain. Pick your choice, because scientists have not said a single word about it.
This autonomous self-replication of defective cells was not enough. It was not enough because the body could rebel against it and stop killing its own cells. Who knows, you might recover.
To prevent this, we are now offered a “vaccine” (self-amplifying mRNA) which injects all of the above plus its own fuel reserves to make sure that the multiplication won’t be stopped by natural means. Now your body will actively multiply trillions of “virus” (“vaccine”) particles no matter what you do. Along the disabling of the natural functions of your cells.
You are no longer a human being. “Scientists” have just turned you into a living Petri dish. They want to inject growth medium along with deadly particles into you, and they want you to become a living lab to culture pathogens for them.
Your body will naturally lose its living energy when your cells stop doing what the Nature or God made them to do. Your lab capacity will be exhausted, sooner or later, because you will have no more healthy cells. If you survive until that moment - because the autoimmune process should first flood your body beyond recognition.
Please correct me if I get anything wrong.