The blood-brain barrier (BBB)

If there is a disturbance in exchange or a perforation, disaster can strike.

I am in the process of developing my knowledge base on neuronal degeneration in humans - and I don’t just mean since humans were subjugated to the COVID-19 shots. This article is based on both i) the idea that the exchange of proteins at the blood-brain barrier (BBB) can become imbalanced (role of perforations in the BBB?), and on ii) the idea of BBB perforation due to ‘directed’ immune-mediated damage. As an example of the former idea, if albumin - a ubiquitous serum protein in humans - stops delivering amyloid beta (Aβ) away from the brain, the result can be accumulation of Aβ and subsequent neuronal degeneration in the form of Alzheimer’s. As an example of the latter, immune-mediated damage to the endothelial cells that comprise the BBB transfected by modified mRNA-containing lipid nanoparticles (LNPs) (this is what I meant by ‘directed’), could lead to perforation of the BBB.

A very important piece of this COVID-19 shot puzzle - especially in the context of the BBB - is whether or not the Mod/Fiz LNPs are specific (ie: designed to transfect specific cell types) or non-specific (can transfect any cell type). I would think they are non-specific.

Schematic adapted from the highly recommended (by me) educational video from Dr. Alzaz’s Medicovisual Visual Medical Lectures. https://www.youtube.com/watch?v=EbAcYNy9ceg

Click on Dr. Alzaz’s video link under the schematic above and skip to 12:15 to find out what Pfizer said when Dr. Alzaz wrote to them regarding his pertinent question as to whether or not their lipid nanoparticles are specific or non-specific. You’ll never guess what they said.

Disclaimer: I am NOT a neuroscientist so please challenge me on any ideas I bring forth here.

I would be remiss if I did not bring attention to Marc Girardot’s work and all that he has brought forth on the subject of the BBB and the effects of the COVID-19 injections, including his bolus theory.

On the BBB

I have learned some absolutely fascinating things about the brain in my research for this article. The BBB is a mechanical blood-filtering system, for all intents and purposes, to prevent big stuff from getting to the brain. The big stuff includes things like antibodies and pathogens that could potentially interfere with proper brain functioning, and functioning of neurons themselves. The BBB works pretty much all thanks to two main cell types: 1. astrocytes and 2. endothelial cells. The endothelial cells line the blood vessels of the BBB, and have special properties including being really smooth and having tight junctions. The astrocytes are seen in green in the picture below and the blood vessels are red. Notice how the astrocytes help to create structure in the gorgeous blood vessel matrix and appear to cling to the vessels. That’s because they do!

3D image of the blood vessels in the BBB (red) made up of endothelial cells that line the inside of the vessels, in snuggly harmony with astrocytes (green) that maintain structure and mediate information transfer. Created at the Karolina Institutet in Stockholm, Sweden https://www.youtube.com/watch?v=da2F7Kaisag

When I think of the endothelial cells that line the vessels of the BBB, I imagine Sacsayhuamán joinery. So many parallels in art and architecture.

By Diego Delso, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=43175184

Not all parts of the brain are protected by the BBB. There is an entire system of organs called the circumventricular (CV) (circum-: around ; ventricular: of ventricle) organs in the brain that are independent of the BBB. CV organs are independent from the BBB out of necessity - they need to be able to exert their respective functions which, for example, can involve detecting and characterizing the very molecules specifically off-limits to the BBB due to potential toxicities or damage potential to neurons. (I wonder if they did not arise independently of the other brain bits?)

One of these organs is the pineal gland (epiphysis). The pineal gland has a direct line to the blood - no filters. This is really important because it is a part of the endocrine system and secretes melatonin to regulate the sleep/wake cycle (circadian rhythm), and to regulate reproductive hormones.

Melatonin readily passes through the blood-brain-barrier and accumulates in the central nervous system at substantially higher levels than exist in the blood. As a result, this molecule exhibits strong neuroprotective effects, especially under the conditions of elevated oxidative stress or intensive neural inflammation.¹

You have to check out this super nerdy cartoon music video on the pineal gland. I had it on repeat. It’s great for kids too. It’s incredible how he easily includes the words suprachiasmatic nucleus into the lyrics of his song. Well done, dude. Well done. I literally was groovin’ in my seat on the floor.

Even though we know the pineal gland secretes melatonin which is essential to chronobiology, this little pinecone-shaped gland is still a bit of a mystery. It is thought to be ‘a typical thing’ that it calcifies in puberty - and even prior to puberty - which affects melatonin production by decreasing it, and also affects the development of bones and sexual organs by accelerating the development of both. This is all very important with regard to puberty.

The calcified parts of the pineal gland (hydroxyapatite crystals) contain the highest fluoride concentrations in the human body (up to 21,000 ppm F), higher than either bone or teeth.²

Fluoride, eh? One of things I remember hearing throughout the course of my life is that fluoride is a neurotoxin and that it can affect the normal-functioning of the pineal gland. But something I learned recently, is that a more dangerous fluoride-containing compound called hydrofluorosilicic acid (HFSA) is being dumped into the water supplies in most places in the United States under the guise of being ‘tooth health promoting’.

Press play…

This dangerous corrosive by-product of the chemical-processing industry is banned in most places on Earth because of its incredible toxicity. It is not a naturally-occurring compound - it is a by-product of the chemical industry. It is not the same as sodium fluoride. So it goes like this: ‘the chemical industry’ had a problem → they had this toxic waste created in massive quantities as by-products of processing and no where to dump it, and no way to label it. So they struck a deal with ‘the right people’ to dispose of it into the water supply. Sounds nuts, right?

But it was easy because 4/5 dentists say that ‘fluoride’ is great for your teeth. Where is that 5th dentist anyway? So combine greed with confusion and you get an ‘agency’/government/media-sanctioned story of wonderful white teeth and healthy kids. The truth, on the other hand, is impossibly sinister. Perhaps the biggest violation here - besides the criminality behind what I just summarized - is the lack of informed consent to the people. Were the people who (have to) actually drink the water part of the decision-making process to put this poison into the water supply? The people probably think that sodium fluoride is added to their drinking water at ‘regulated’ concentrations. But the people would be wrong. What they are not told is that: 1. HFSA, not sodium fluoride, is being added to the water supply at certain sites, 2. HFSA is not the same as sodium fluoride at all, and 3. different people do have different tolerances for fluoride consumption but ultimately, no amount is safe.

Does fluoride accumulate in the pineal gland? Apparently, it does.³ And the result of this? Dysregulated melatonin and accelerated sexual development. Accelerated sexual development? Are people aware of this? I thought the bigger and taller girls who went through puberty earlier were messed up from hormones in cow’s milk. Seriously. I actually did think this. I don’t say this without personal experience. There was a staggering difference in the physical size and timing of menstruation in the generation of girls that came after me. It was noticeable. I thought more hormones were being added to the cow-milk and having a direct effect on the development of girls. But, maybe it’s the fluoride, both in the water, and found ubiquitously in hundreds of products that we use every day, affecting the pineal gland? Maybe it’s just another coincidence?

P.S. The pineal gland is also referred to as the third eye and has been proposed to produce Dimethyltryptamine (DMT).⁴ I also refer everyone to the genius of Alex Grey for supernatural painted renditions of the ‘third eye’..

Drawing from René Descartes' (1596-1650) in "Treatise of Man" supposing the function of the pineal gland.

Another CV organ outside of BBB protection is called the area postrema. Its role is to detect circulating chemical messengers in the blood and to transduce them into neural signals and networks.⁵⁶ It manages sympathetic and vagal responses. Specifically and importantly, it detects changes in circulating volume and blood pressure via vasopressin and angiotensin-II (ACE-II) detection. When I saw the ACE-II, it made me go: hmmm. It also has a role in detection of changes in hormones relating to vomiting, thirst and hunger. Pretty important.

The circumventricular organs in the human brain: Kahle's 1979 Atlas de poche d'anatomie (tome 3 : Système nerveux et organes des sens

But I will leave any conclusions about the effects of SARS-CoV-2 or the COVID-19 shots on the CV organs for now.

Let’s get back to our ‘leaky’ BBB idea.

Let’s frame this idea in the context of the modified mRNA-containing LNP technology, and assume that the LNPs are non-specific. We could be looking at BBB penetration due to the small size of the LNPs, and/or damage due to transfection of the BBB endothelial cells and damage/perforation due to immune responses in the case of transfection. So we’re talking about two different things here: 1. LNPs entering the brain because they’re tiny and transfecting brain cells, etc… and/or 2. transfection of the endothelial cells that make up the BBB leading to perforation of the BBB itself.

One of the reasons for research and development of LNPs, after all, was for delivery of drugs to the brain by penetrating the BBB, so we know this can happen.⁷⁸ The following video was made in 2016 as part of an honor’s project. I want everyone to think about that. This is how it happens. Products not intended for malevolence. Just a few kids who are nerdin’ it up lookin’ for a good grade.

So entry of biological materials into the brain, like nanoparticles carrying my united states of whatever, is absolutely possible in the context of the BBB. This is the first important point.

The blood-brain barrier (BBB) acts as the regulatory interface by controlling the rate of exchange of substances between the central nervous system (CNS) and the blood. As such, the BBB serves homeostatic, nutritive, and communicative roles. Alteration in BBB integrity or in its higher functions can result in dysfunction and disease of the CNS.⁹

So if the integrity of this regulatory interface is breached by exogenous molecules containing modified mRNA for example, then as indicated above, either - or both - 1. and 2. will ensue. In the case of 1., I imagine a scenario where tons of LNPs have infiltrated the brain by readily passing through the BBB and by design, dumped their modified mRNA payloads in whatever cells they had transfected. Now remember, these are brain cells. Any cell that is transfected, will produce the foreign proteins encoded by the modified mRNA, chew them up into peptides, and mount them on MHC molecules (and also impregnate some on their cell surfaces) for immune cell targeted destruction. In this case, the cell is killed → infiltrates (lymphocytic and cytokine/chemokine) → inflammation→ damage → wound healing → scarring.¹⁰ Bad for brain. This should be easy to ‘see’ with imaging, shouldn’t it?

In the case of 2., the BBB itself becomes compromised and this same process of immune-mediated damage would occur to the endothelial cells of the barrier. And you guessed it, perforation of the barrier itself could ensue due to localized destruction of endothelial cells. Think about that. If the BBB itself is perforable by the ability of the LNPs to transfect their endothelial cells, this is a disaster.

If you think about it a little more, this could explain why we are seeing so many neurological disorders being reported to VAERS and other pharmacovigilance databases in the context of the modified mRNA LNP COVID-19 shots. Things like: neuropathy, white matter lesions and increased rates of Parkinson’s, multiple sclerosis and Alzheimer’s.

Just as a reminder, as of August 18, 2023, there are 644,085 reports of neurological-related adverse events. Factor in the URF of 31 → 19,966,635 actual neurological injuries. Keep this on hold for a second.

Let’s get back to the bit on the non-COVID-19 shot-related BBB/neuronal degeneration imposed by deposition and accumulation of amyloid beta proteins.

On amyloid beta (Aβ)

One of the critical players in the transport of Aβ (that incidentally is produced throughout the body whereby its clearance relies on carrier proteins¹¹¹²¹³¹⁴¹⁵¹⁶¹⁷), and subsequent maintenance of homeostasis of various proteins in and out of the brain, is albumin. Albumin is one of these carrier proteins.

Aβ is the by-product of amyloid precursor protein which is an integral membrane protein of neurons, although it can be found in tissues all over the body. When it is cleaved as part of' ‘normal’ processes, beta amyloid is freed and is subsequently scheduled for degradation/removal so that it doesn’t accumulate in the brain. Defects in - or blockage of - removal of Aβ has been associated with neurodegenerative diseases. This is because if not trafficked away, Aβ can accumulate near the synaptic junctions of neurons decreasing electrical conductivity between them. This is where problems ensue. This is also implicated as the etiology for Alzheimer’s.

Blockage of Aβ transcytosis across the endothelium accelerates the abnormal deposition of Aβ and is closely associated with neuronal degeneration.¹⁸¹⁹²⁰

On albumin

Human serum albumin is produced in the liver and constitutes about half of the total serum protein content. It binds to and transports all sorts of things like hormones, fatty acids and proteins - like Aβ - and also acts as a pH buffer and helps to maintain oncotic pressure. Because it can bind readily to Aβ and also is a potent inhibitor of Aβ polymerization, it has been implicated in Alzheimer’s disease whereby low levels of serum albumin are positively correlated with neurodegeneration.²¹ ‘A reduction in Aβ binding to serum albumin in the blood may lead to a decrease in the capacity for Aβ excretion from the brain to the blood, resulting in Aβ deposition in the brain’.²²

Albumin has a vital role at the interface of the blood, and the cerebrospinal fluid (CSF), and the brain, to bind to and carry away certain proteins like Aβ.

We also know that if the BBB does become leaky, albumin can get to places it shouldn’t be able to ‘normally’, and disease can ensue and/or be exacerbated.

Leakage of the blood–brain barrier (BBB) is a common pathological feature in multiple sclerosis (MS). Following a breach of the BBB, albumin, the most abundant protein in plasma, gains access to CNS tissue where it is exposed to an inflammatory milieu and tissue damage, e.g., demyelination.²³

So if normal processes go out of balance, disease ensues. Any breach/ or perforation or leakiness of the BBB is a one-way ticket to disease. That’s Jessie’s (as opposed to Jerry’s) final thought.

Now I have a question for my readers. What do you think is happening here? Do you think that the damages we are seeing since 2021 are due solely to the COVID-19 shots, or do you think perhaps there is some kind of synergistic mechanism of damage being done - perhaps the combination of fluoride-induced damage and the shots? Aging? Vitamin D levels? ROS levels? Hell, it may even be possible that the BBB is being made leaky by the radio frequency (RF) radiation we are exposed to every day from our devices as proposed by neurosurgeon Dr. Leif Salford in 1988.²⁴²⁵²⁶²⁷ Perhaps this is why people are succumbing to worsening of pathologies from the shots because of a possible link between RF radiation and increases in oxidative stress.²⁸²⁹³⁰³¹³²³³³⁴³⁵³⁶ By the way, there are A LOT of peer-reviewed publications on this subject matter.

Also by the way, if someone wants to contact Moderna or Pfizer to ask them about whether or not their LNPs are non-specific, that would be awesome. They didn’t answer me when I asked. I will try again.

Although this article did get pretty long, I didn’t even scratch the surface of my own questions so I will keep researching this topic and relay my ideas and findings as I discover them. At this point, my mind is wide open.

I want to thank Marc for a fabulous back-and-forth yesterday as well. He said I could post a photo of some of his kittens. So here they are. Who would get any work done with these eggies around!?

El Gato Malo’s theory that it was, in fact, cats that are responsible for the increase in Amazon’s business in order to get more boxes, is true.

1. Tan DX. Melatonin and brain. Curr Neuropharmacol. 2010 Sep;8(3):161. doi: 10.2174/157015910792246263. PMID: 21358966; PMCID: PMC3001209.

2. https://fluoridealert.org/issues/health/pineal-gland/

3. Jennifer Anne Luke. The Effect of Fluoride on the Physiology of the Pineal Gland, 1997. A dissertation submitted to the School of Biological Sciences, University of Surrey, in fulfillment of the requirements for the Degree of Doctor of Philosophy. https://www.fluoridealert.org/wp-content/uploads/luke-1997.pdf

4. William A. Banks and others, Permeability of the Blood-Brain Barrier to Albumin and Insulin in the Young and Aged SAMP8 Mouse, The Journals of Gerontology: Series A, Volume 55, Issue 12, 1 December 2000, Pages B601–B606, https://doi.org/10.1093/gerona/55.12.B601.

5. https://en.wikipedia.org/wiki/Area_postrema

6. https://derangedphysiology.com/main/cicm-primary-exam/required-reading/nervous-system/Chapter%20111/blood-brain-barrier

7. Shankar R, Joshi M, Pathak K. Lipid Nanoparticles: A Novel Approach for Brain Targeting. Pharm Nanotechnol. 2018;6(2):81-93. doi: 10.2174/2211738506666180611100416. PMID: 29886842.

8. Haifei He, Ju Yao, Yingxin Zhang, Yidan Chen, Kaifeng Wang, Robert J. Lee, Bo Yu, Xiaomin Zhang, Solid lipid nanoparticles as a drug delivery system to across the blood-brain barrier, Biochemical and Biophysical Research Communications, Volume 519, Issue 2, 2019, Pages 385-390, ISSN 0006-291X, https://doi.org/10.1016/j.bbrc.2019.09.017.

9. William A. Banks and others, Permeability of the Blood-Brain Barrier to Albumin and Insulin in the Young and Aged SAMP8 Mouse, The Journals of Gerontology: Series A, Volume 55, Issue 12, 1 December 2000, Pages B601–B606, https://doi.org/10.1093/gerona/55.12.B601

10. Smith, N., Gachulincova, I., Ho, D. et al. An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles. Sci Rep 6, 22595 (2016). https://doi.org/10.1038/srep22595

11. Lame ME, Chambers EE, Blatnik M. Quantitation of amyloid beta peptides Aβ1–38, Aβ1–40, and Aβ1–42 in human cerebrospinal fluid by ultra-performance liquid chromatography–tandem mass spectrometry. Analyt Biochem. (2011) 419:133–9. doi: 10.1016/j.ab.2011.08.010

12. Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, Davis D, et al. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature. (1992) 359:325–7. doi: 10.1038/359325a0

13. Dergunov AD. Competition between serum amyloid protein and apoprotein E for binding with human serum albumin. Bull Exp Biol Med. (1992) 114:1791–3. doi: 10.1007/BF00840464

14. Liu Y-H, Xiang Y, Wang Y-R, Jiao S-S, Wang Q-H, Bu X-L, et al. Association between serum amyloid-beta and renal functions: implications for roles of kidney in amyloid-beta clearance. Mol Neurobiol. (2015) 52:115–9. doi: 10.1007/s12035-014-8854-y

15. Marr R, Masliah E. Amyloid-Beta Clearance in Alzheimer's Disease. Frontiers Media SA (2015). Available online at: https://books.google.com/books/about/Amyloid_beta_clearance_in_Alzheimer_s_di.html?hl=&id=qfdBCgAAQBAJ

16. Yamamoto K, Shimada H, Ataka S, Miki T. Serum levels of albumin-beta-amyloid complexes are usable biomarkers for Alzheimer's disease. Alzheimer. Dement. (2013) 9:P233–4. doi: 10.1016/j.jalz.2013.05.445

17. Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, et al. Clearance of amyloid-β by circulating lipoprotein receptors. Nat Med. (2007) 13:1029–31. doi: 10.1038/nm1635

18. Simon MJ, Iliff JJ. Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease. Biochim Biophys Acta. (2016) 1862:442–51. doi: 10.1016/j.bbadis.2015.10.014

19. Weller RO, Carare RO, Boche D. Amyloid: vascular and parenchymal. In: Reference Module in Neuroscience and Biobehavioral Psychology. (2017). doi: 10.1016/B978-0-12-809324-5.02590-6

20. Arbel-Ornath M, Hudry E, Eikermann-Haerter K, Hou S, Gregory JL, Zhao L, et al. Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models. Acta Neuropathol. (2013) 126:353–64. doi: 10.1007/s00401-013-1145-2

21. Ahn SM, Byun K, Cho K, Kim JY, Yoo JS, Kim D, Paek SH, Kim SU, Simpson RJ, Lee B. Human microglial cells synthesize albumin in brain. PLoS One. 2008 Jul 30;3(7):e2829. doi: 10.1371/journal.pone.0002829. PMID: 18665237; PMCID: PMC2483733

22. Stanyon HF, Viles JH. Human serum albumin can regulate amyloid-beta peptide fiber growth in the brain interstitium: implications for Alzheimer disease.J Biol Chem2012;287:28163–28168

23. LeVine, S.M. Albumin and multiple sclerosis. BMC Neurol 16, 47 (2016). https://doi.org/10.1186/s12883-016-0564-9

24. K Sri N. Mobile Phone Radiation: Physiological & Pathophysiologcal Considerations. Indian J Physiol Pharmacol. 2015 Apr-Jun;59(2):125-35. PMID: 26685499.

25. Hardell L, Sage C. Biological effects from electromagnetic field exposure and public exposure standards. Biomed Pharmacother. 2008 Feb;62(2):104-9. doi: 10.1016/j.biopha.2007.12.004. Epub 2007 Dec 31. PMID: 18242044.

26. Behari J. Biological responses of mobile phone frequency exposure. Indian J Exp Biol. 2010 Oct;48(10):959-81. PMID: 21299039.

27. Otto M, von Mühlendahl KE. Electromagnetic fields (EMF): do they play a role in children's environmental health (CEH)? Int J Hyg Environ Health. 2007 Oct;210(5):635-44. doi: 10.1016/j.ijheh.2007.07.007. Epub 2007 Aug 31. PMID: 17765660.

28. Repacholi MH. Low-level exposure to radiofrequency electromagnetic fields: health effects and research needs. Bioelectromagnetics. 1998;19(1):1-19. PMID: 9453702.

29. Possible health hazards from exposure to power-frequency electric and magnetic fields--a COMAR Technical Information Statement. IEEE Eng Med Biol Mag. 2000 Jan-Feb;19(1):131-7. PMID: 10659440.

30. Moulder JE, Foster KR, Erdreich LS, McNamee JP. Mobile phones, mobile phone base stations and cancer: a review. Int J Radiat Biol. 2005 Mar;81(3):189-203. doi: 10.1080/09553000500091097. PMID: 16019928.

31. Akkam Y, A Al-Taani A, Ayasreh S, Almutairi A, Akkam N. Correlation of Blood Oxidative Stress Parameters to Indoor Radiofrequency Radiation: A Cross Sectional Study in Jordan. Int J Environ Res Public Health. 2020 Jun 29;17(13):4673. doi: 10.3390/ijerph17134673. PMID: 32610554; PMCID: PMC7369753.

32. Yüksel M, Nazıroğlu M, Özkaya MO. Long-term exposure to electromagnetic radiation from mobile phones and Wi-Fi devices decreases plasma prolactin, progesterone, and estrogen levels but increases uterine oxidative stress in pregnant rats and their offspring. Endocrine. 2016 May;52(2):352-62. doi: 10.1007/s12020-015-0795-3. Epub 2015 Nov 14. PMID: 26578367.

33. Zha XD, Wang WW, Xu S, Shang XJ. [Impacts of electromagnetic radiation from cellphones and Wi-Fi on spermatogenesis]. Zhonghua Nan Ke Xue. 2019 May;25(5):451-455. Chinese. PMID: 32216233.

34. Chu KY, Khodamoradi K, Blachman-Braun R, Dullea A, Bidhan J, Campbell K, Zizzo J, Israeli J, Kim M, Petrella F, Ibrahim E, Ramasamy R. Effect of Radiofrequency Electromagnetic Radiation Emitted by Modern Cellphones on Sperm Motility and Viability: An In Vitro Study. Eur Urol Focus. 2023 Jan;9(1):69-74. doi: 10.1016/j.euf.2022.11.004. Epub 2022 Nov 12. PMID: 36379868; PMCID: PMC9928907.

35. Gevrek F, Aydin D, Ozsoy S, Aygun H, Bicer C. Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system. Bratisl Lek Listy. 2017;118(11):676-683. doi: 10.4149/BLL_2017_128. PMID: 29216724.

36. Kamali K, Taravati A, Sayyadi S, Gharib FZ, Maftoon H. Evidence of oxidative stress after continuous exposure to Wi-Fi radiation in rat model. Environ Sci Pollut Res Int. 2018 Dec;25(35):35396-35403. doi: 10.1007/s11356-018-3482-0. Epub 2018 Oct 21. PMID: 30343375.