My mother died of Alzheimer’s, my sister and first cousin died of ALS. One of many reasons I avoided the jab was the “prion-like spike proteins”, as they were described in early 2021. Now I know even more. Thank you !
Description: MIT SCIENTIST CONNECTS MRNA SHOTS TO BRAIN DISEASE Senior Research Scientist at MIT, Stephanie Seneff, discusses the recent paper she co-authored with Peter McCullough, which shines a light on science showing that mRNA vaccines may be causing widespread illness and death. #StephanieSeneff #Prions #VaccineSafety POSTED: April 22, 2022
2. In Substack article at https://stevekirsch.substack.com/p/twitter-made-a-huge-mistake-i-was?s=r Steve Kirsch wrote "The latest news about prion diseases is devastating." There's a whole lot more in this highly readable Substack, as you would expect from Mr. Kirsch 🙂 His substack mentions and links to the work of Dr. Byram Bridle and Dr. Paul Oosterhuis, among others.
STOP 🛑 THE SHOT 💉 NOW TO AVOID THE ZOMBIE 🧟♀️🧟♂️ APOCALYPSE THAT'S COMING!
Fascinating and informative - thank you for this excellent piece.
Stephanie Seneff and Greg Nigh wrote about prion disease risks from the injections in a May 2021 paper: Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19.
“...Furthermore, researchers have identified a signature motif linked to susceptibility to misfolding into toxic oligomers, called the glycine zipper motif. It is characterized by a pattern of two glycine residues spaced by three intervening amino acids, represented as GxxxG. The bovine prion linked to MADCOW has a spectacular sequence of ten GxxxGs in a row (see uniprot.org/uniprot/P10279).
More generally, the GxxxG motif is a common feature of transmembrane proteins, and the glycines play an essential role in cross-linking α-helices in the protein (Mueller et al., 2014). Prionproteins become toxic when the α-helices misfold as β-sheets, and the protein is then impaired in its ability to enter the membrane (Prusiner, 1982). Glycines within the glycine zipper transmembrane motifs in the amyloid-β precursor protein (APP) play a central role in the misfolding of amyloid-β linked to Alzheimer’s disease (Decock et al., 2016). APP contains a total of four GxxxG motifs.
When considering that the SARS-CoV-2 spike protein is a transmembrane protein, and that it contains fiveGxxxG motifs in its sequence (see uniprot.org/uniprot/P0DTC2), it becomes extremely plausible that it could behave as a prion. One of the GxxxG sequences is present within its membrane fusion domain. Recall that the mRNA vaccines are designed with an altered sequence that replaces two adjacent amino acids in the fusion domain with a pair of prolines. This is done intentionally in order to force the protein to remain in its open state and make it harder for it to fuse with the membrane. This seems to us like a dangerous step towards misfolding potentially leading to prion disease.
A paper published by J. Bart Classen (2021) proposed that the spike protein in the mRNA vaccines could cause prion-like diseases, in part through its ability to bind to many known proteins andinduce their misfolding into potential prions. Idrees and Kumar (2021) have proposed that the spike protein’s S1 component is prone to act as a functional amyloid and form toxic aggregates. These authors wrote that S1 has the ability “to form amyloid and toxic aggregates that can act as seeds to aggregate many of the misfolded brain proteins and can ultimately lead to neurodegeneration.”
According to Tetz and Tetz (2020), the form of the spike protein in SARS-CoV-2 has prion regions that are not present in the spike proteins for other coronaviruses. While this was reported in a non-peer-reviewed article, the authors had published a previous paper in 2018 identifying prion-like regions in multiple eukaryotic viruses, so they have considerable expertise in this area (Tetz and Tetz, 2018).
A final point here relates to information about the Pfizer vaccine in particular. The European Medicines Agency (EMA) Public Assessment Report is a document submitted to gain approval to market the vaccine in Europe. It describes in detail a review of the manufacturing process as well as a wide range of associated testing data. One concerning revelation is the presence of “fragmented species” of RNA in the injection solution. These are RNA fragments resulting from early termination of the process of transcription from the DNA template. These fragments, if translated by the cell following injection, would generate incomplete spike proteins, again resulting in altered and unpredictable three-dimensional structure and a physiological impact that is at best neutral and at worst detrimental to cellular functioning. There were considerably more of these fragmented forms of RNA found in the commercially manufactured products than in the products used in clinical trials. The latter wereproduced via a much more tightly controlled manufacturing process.Pfizer claims the RNA fragments “likely... will not result in expressed proteins” due to their assumed rapid degradation within the cell.”
No data was presented to rule out protein expression, though, leaving the reviewers to comment, “These [fragmented RNA] forms are poorly characterised, and the limited data provided for protein expression do not fully address the uncertainties relating to the risk of translating proteins/peptides other thanthe intended spike protein” (EMA 2020). To our knowledge no data has been forthcoming since that time.
While we are not asserting that non-spike proteins generated from fragmented RNA would be misfolded or otherwise pathological, we believe they would at least contribute to the cellular stress that promotes prion-associated conformational changes in the spike protein that is present..”
Yet another thing to avoid making my jabbed and boosted friends and loved ones aware of…unless any of them tells me they want another jab. I’m guessing that a lot of the unjabbed have been trying to figure out when, if ever, it would be kinder to level with their “fully vaccinated” loved ones about the harms that are being uncovered, than not to level with them. After a point, the evidence will be unavoidable and even the most in denial will be looking at reasons to be terrified. When it comes to my double-jabbed + one booster husband, who so far seems fine, I’ve got a simple stratagem should he become aware of and frightened by the scary info that’s surfacing: “I think they gave you a placebo.”
This article caused me to sign up for a paid account. Very well done, Unacceptable Jessica. In saner times this article would be a nascent publishable journal article. Pleased to see knowledge of Stuart Kauffman's early autocatalytic sets paper getting attention. I've been half expecting him to receive a Nobel Prize but if so they better hurry, as he's pushing 90. FYI: DARPA did a lot of cross-disciplinary research on prions, prion diseases, and weaponization of same starting in the late 1990s through at least 2016.
I brought this topic awhile ago. In a number of dog breeds amyliodosis is a genetic disorder that is thought to have been brought on by inbreeding. It often shows about about five years of age when the dog gets stressed and their immune system goes into uncontrollable overdrive. Ending in an autoimmune over drive producing protective white blood cells and overloading the liver and death.
I am no scientist and I think I had high school biology but my teenage years and a little beyond (to be honest) are a bit of a blur. I was a wild child and school wasn't important. I wish now that I am der this wasn't true. So I will just say I realize that what is happening, shouldn't be happening and since the rollout of these shots has taken a tremendous up turn to degenerate the health of the ones that took this shot. I worry about my parents. I don't know if they took more than 1 shot (it's not a place that I can easily go by asking.) My Dad is in his mid 60' and my mom is in her mid 70's. They wouldn't listen to me from the beginning. It's crazy how so many people that didn't have a college education could see through the lies and the very educated people couldn't (in many cases.) Even some of the people (not you Jessica) that we probably all follow didn't see the writing on the wall because of their own biases (maybe they worked in this field forever or on its periphery. ) I guess in some ways it was a service to not know "the science". I feel like it made it easier for me to see the bullshit going on with the people "in charge of the science." Jessica I thank you for everything you bring to us. I like data even if I don't completely understand I can get the gist of it. I thank God above all things that I was given the ability to see through the lies and not get bogged down with fear.
I thought this was interesting when looking into prion diseases and the Autonomic Nervous System, considering all those that ended up with long covid (POTS) = a form of autonomic nervous system dysfunction), or covid vaccine injury POTS.
After reading this, I can understand how this little local 5 year old girl’s immune system imploded, and she died within a week of getting the covid vaccine. Leaky Vaccines! A friend told me her parents got her vaccinated for kindergarten. So tragic, and the parents were quick to cremate her remains. I imagine that’s how they had to deal with it….. I don’t know…it’s just horrible. Now the CDC, FDA, NIH, Fauci and the gang can rely on shamed parents to get rid of the evidence…and help cover up these crimes against humanity.
Prion disease seems like a portal system to utter destruction to the human body.
Thank you for the explanation. Walter Chestnut, Jessica Rose, Igor Chudov, and Steve Kirsch have all addressed prion-like diseases and / or amyloidosis in some form. What chills me is that, if this is an issue, I can envision a scenario where cures or treatments are "siloed" out of some misguided national security concern. Morose speculation no doubt, but I find it hard to believe that US biodefense people aren't flagging this as a potential risk. Surely they are looking at this along with treatments, and we know they don't show any interest in protecting the population as a whole. Dr. Strangelove kind of stuff.
This is great reporting and will save lives. I agree on the amyloid danger but would like to add another possibility that might explain why prior disease from the jabs are not affecting many more people. It all comes down to disease carry capacity. For example, people with HIV have low DCC because of depletion of CD4 lymphocytes. That means any new infection will release a higher amount of neutrophils, which cause massive inflammation, than lymphocytes like CD4 cells that kill viruses. The excess neutrophils for nets like spiders webs to trap the viruses. These neutrophil traps are broken down in the liver to amyloid plaques. Can this explain amyloidosis better, given it would only affect immune compromised, or elderly or auto-immune people? Which ever is correct you have cast a light on a very dark area and saved lives. Lumbrokinase and Nattikinase are vital for people affected. Natto is easy to make from fermented soy, and it is delicious. Once again, great and fearless reporting.
I tried to understand this article, but even after coffee, I couldn’t. Nonetheless, my takeaway is that this prion stuff will be bad — very bad.
All I can see are images of eggs 🥚 frying in a pan 🍳or boiling in a pot 🥘as their proteins are being irreversibly changed by the application of heat 🥵, uh, shots 💉.
Basically, this is your brain 🧠 on drugs if you take these shots. If only I could convince friends and family; but once their brains have been washed, there’s no going back.
My mother died of Alzheimer’s, my sister and first cousin died of ALS. One of many reasons I avoided the jab was the “prion-like spike proteins”, as they were described in early 2021. Now I know even more. Thank you !
Perhaps you should change your "stage" name to "Amazing Jessica" - definitely worth supporting...
I would need to re-read your articles a couple of times (as a non-doctor - of course) - thank you so much for your effort!
I wish I was as good in my job as you are in yours...
I'll study this when I have some coffee in my veins. 💉☕
Wanted to mention two other resources for people wanting to explore this scary brain stuff 👾🧠 (of course, there are more!):
1. Dr. Stephanie Seneff, Senior MIT Scientist, has been warning about prion disease. See The Highwire coverage video at https://thehighwire.com/videos/mit-scientist-connects-mrna-shots-to-brain-disease/
Description: MIT SCIENTIST CONNECTS MRNA SHOTS TO BRAIN DISEASE Senior Research Scientist at MIT, Stephanie Seneff, discusses the recent paper she co-authored with Peter McCullough, which shines a light on science showing that mRNA vaccines may be causing widespread illness and death. #StephanieSeneff #Prions #VaccineSafety POSTED: April 22, 2022
2. In Substack article at https://stevekirsch.substack.com/p/twitter-made-a-huge-mistake-i-was?s=r Steve Kirsch wrote "The latest news about prion diseases is devastating." There's a whole lot more in this highly readable Substack, as you would expect from Mr. Kirsch 🙂 His substack mentions and links to the work of Dr. Byram Bridle and Dr. Paul Oosterhuis, among others.
STOP 🛑 THE SHOT 💉 NOW TO AVOID THE ZOMBIE 🧟♀️🧟♂️ APOCALYPSE THAT'S COMING!
Fascinating and informative - thank you for this excellent piece.
Stephanie Seneff and Greg Nigh wrote about prion disease risks from the injections in a May 2021 paper: Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19.
https://ijvtpr.com/index.php/IJVTPR/article/view/23/51
“...Furthermore, researchers have identified a signature motif linked to susceptibility to misfolding into toxic oligomers, called the glycine zipper motif. It is characterized by a pattern of two glycine residues spaced by three intervening amino acids, represented as GxxxG. The bovine prion linked to MADCOW has a spectacular sequence of ten GxxxGs in a row (see uniprot.org/uniprot/P10279).
More generally, the GxxxG motif is a common feature of transmembrane proteins, and the glycines play an essential role in cross-linking α-helices in the protein (Mueller et al., 2014). Prionproteins become toxic when the α-helices misfold as β-sheets, and the protein is then impaired in its ability to enter the membrane (Prusiner, 1982). Glycines within the glycine zipper transmembrane motifs in the amyloid-β precursor protein (APP) play a central role in the misfolding of amyloid-β linked to Alzheimer’s disease (Decock et al., 2016). APP contains a total of four GxxxG motifs.
When considering that the SARS-CoV-2 spike protein is a transmembrane protein, and that it contains fiveGxxxG motifs in its sequence (see uniprot.org/uniprot/P0DTC2), it becomes extremely plausible that it could behave as a prion. One of the GxxxG sequences is present within its membrane fusion domain. Recall that the mRNA vaccines are designed with an altered sequence that replaces two adjacent amino acids in the fusion domain with a pair of prolines. This is done intentionally in order to force the protein to remain in its open state and make it harder for it to fuse with the membrane. This seems to us like a dangerous step towards misfolding potentially leading to prion disease.
A paper published by J. Bart Classen (2021) proposed that the spike protein in the mRNA vaccines could cause prion-like diseases, in part through its ability to bind to many known proteins andinduce their misfolding into potential prions. Idrees and Kumar (2021) have proposed that the spike protein’s S1 component is prone to act as a functional amyloid and form toxic aggregates. These authors wrote that S1 has the ability “to form amyloid and toxic aggregates that can act as seeds to aggregate many of the misfolded brain proteins and can ultimately lead to neurodegeneration.”
According to Tetz and Tetz (2020), the form of the spike protein in SARS-CoV-2 has prion regions that are not present in the spike proteins for other coronaviruses. While this was reported in a non-peer-reviewed article, the authors had published a previous paper in 2018 identifying prion-like regions in multiple eukaryotic viruses, so they have considerable expertise in this area (Tetz and Tetz, 2018).
A final point here relates to information about the Pfizer vaccine in particular. The European Medicines Agency (EMA) Public Assessment Report is a document submitted to gain approval to market the vaccine in Europe. It describes in detail a review of the manufacturing process as well as a wide range of associated testing data. One concerning revelation is the presence of “fragmented species” of RNA in the injection solution. These are RNA fragments resulting from early termination of the process of transcription from the DNA template. These fragments, if translated by the cell following injection, would generate incomplete spike proteins, again resulting in altered and unpredictable three-dimensional structure and a physiological impact that is at best neutral and at worst detrimental to cellular functioning. There were considerably more of these fragmented forms of RNA found in the commercially manufactured products than in the products used in clinical trials. The latter wereproduced via a much more tightly controlled manufacturing process.Pfizer claims the RNA fragments “likely... will not result in expressed proteins” due to their assumed rapid degradation within the cell.”
No data was presented to rule out protein expression, though, leaving the reviewers to comment, “These [fragmented RNA] forms are poorly characterised, and the limited data provided for protein expression do not fully address the uncertainties relating to the risk of translating proteins/peptides other thanthe intended spike protein” (EMA 2020). To our knowledge no data has been forthcoming since that time.
While we are not asserting that non-spike proteins generated from fragmented RNA would be misfolded or otherwise pathological, we believe they would at least contribute to the cellular stress that promotes prion-associated conformational changes in the spike protein that is present..”
"Figure 6: Nancy Pelosi’s eyebrows." 🤣🤣🤣
Yet another thing to avoid making my jabbed and boosted friends and loved ones aware of…unless any of them tells me they want another jab. I’m guessing that a lot of the unjabbed have been trying to figure out when, if ever, it would be kinder to level with their “fully vaccinated” loved ones about the harms that are being uncovered, than not to level with them. After a point, the evidence will be unavoidable and even the most in denial will be looking at reasons to be terrified. When it comes to my double-jabbed + one booster husband, who so far seems fine, I’ve got a simple stratagem should he become aware of and frightened by the scary info that’s surfacing: “I think they gave you a placebo.”
This article caused me to sign up for a paid account. Very well done, Unacceptable Jessica. In saner times this article would be a nascent publishable journal article. Pleased to see knowledge of Stuart Kauffman's early autocatalytic sets paper getting attention. I've been half expecting him to receive a Nobel Prize but if so they better hurry, as he's pushing 90. FYI: DARPA did a lot of cross-disciplinary research on prions, prion diseases, and weaponization of same starting in the late 1990s through at least 2016.
I'm no kind of scientist and don't pretend to fully understand this piece, but jeez I'm not happy.
I brought this topic awhile ago. In a number of dog breeds amyliodosis is a genetic disorder that is thought to have been brought on by inbreeding. It often shows about about five years of age when the dog gets stressed and their immune system goes into uncontrollable overdrive. Ending in an autoimmune over drive producing protective white blood cells and overloading the liver and death.
Aren’t Shar Pei’s adorable.
https://theagingviking.substack.com/p/arent-shar-peis-adorable?r=bm3n6&s=w&utm_campaign=post&utm_medium=web
To expand, Unacceptably Brilliant Jessica!
https://wmcresearch.substack.com/p/the-prioloid-spike-protein-of-sars?s=w
I am no scientist and I think I had high school biology but my teenage years and a little beyond (to be honest) are a bit of a blur. I was a wild child and school wasn't important. I wish now that I am der this wasn't true. So I will just say I realize that what is happening, shouldn't be happening and since the rollout of these shots has taken a tremendous up turn to degenerate the health of the ones that took this shot. I worry about my parents. I don't know if they took more than 1 shot (it's not a place that I can easily go by asking.) My Dad is in his mid 60' and my mom is in her mid 70's. They wouldn't listen to me from the beginning. It's crazy how so many people that didn't have a college education could see through the lies and the very educated people couldn't (in many cases.) Even some of the people (not you Jessica) that we probably all follow didn't see the writing on the wall because of their own biases (maybe they worked in this field forever or on its periphery. ) I guess in some ways it was a service to not know "the science". I feel like it made it easier for me to see the bullshit going on with the people "in charge of the science." Jessica I thank you for everything you bring to us. I like data even if I don't completely understand I can get the gist of it. I thank God above all things that I was given the ability to see through the lies and not get bogged down with fear.
I thought this was interesting when looking into prion diseases and the Autonomic Nervous System, considering all those that ended up with long covid (POTS) = a form of autonomic nervous system dysfunction), or covid vaccine injury POTS.
https://www.hindawi.com/journals/ipid/2010/747892/
After reading this, I can understand how this little local 5 year old girl’s immune system imploded, and she died within a week of getting the covid vaccine. Leaky Vaccines! A friend told me her parents got her vaccinated for kindergarten. So tragic, and the parents were quick to cremate her remains. I imagine that’s how they had to deal with it….. I don’t know…it’s just horrible. Now the CDC, FDA, NIH, Fauci and the gang can rely on shamed parents to get rid of the evidence…and help cover up these crimes against humanity.
Prion disease seems like a portal system to utter destruction to the human body.
Thank you for the explanation. Walter Chestnut, Jessica Rose, Igor Chudov, and Steve Kirsch have all addressed prion-like diseases and / or amyloidosis in some form. What chills me is that, if this is an issue, I can envision a scenario where cures or treatments are "siloed" out of some misguided national security concern. Morose speculation no doubt, but I find it hard to believe that US biodefense people aren't flagging this as a potential risk. Surely they are looking at this along with treatments, and we know they don't show any interest in protecting the population as a whole. Dr. Strangelove kind of stuff.
Wow! Thank you Dr. Rose. This is very informative. I bet this is what you do for fun! Wish I could have had a teacher like you growing up. Brainy fun!
This is great reporting and will save lives. I agree on the amyloid danger but would like to add another possibility that might explain why prior disease from the jabs are not affecting many more people. It all comes down to disease carry capacity. For example, people with HIV have low DCC because of depletion of CD4 lymphocytes. That means any new infection will release a higher amount of neutrophils, which cause massive inflammation, than lymphocytes like CD4 cells that kill viruses. The excess neutrophils for nets like spiders webs to trap the viruses. These neutrophil traps are broken down in the liver to amyloid plaques. Can this explain amyloidosis better, given it would only affect immune compromised, or elderly or auto-immune people? Which ever is correct you have cast a light on a very dark area and saved lives. Lumbrokinase and Nattikinase are vital for people affected. Natto is easy to make from fermented soy, and it is delicious. Once again, great and fearless reporting.
I tried to understand this article, but even after coffee, I couldn’t. Nonetheless, my takeaway is that this prion stuff will be bad — very bad.
All I can see are images of eggs 🥚 frying in a pan 🍳or boiling in a pot 🥘as their proteins are being irreversibly changed by the application of heat 🥵, uh, shots 💉.
Basically, this is your brain 🧠 on drugs if you take these shots. If only I could convince friends and family; but once their brains have been washed, there’s no going back.