%RNA integrity in the context of the COVID-19 shots
Why is this important? Is it related to SAE reporting frequency?
I had a chat with my dear buddy Mathew Crawford yesterday on his podcast Rounding the Earth. You can watch that here. As detail corrections, the spike protein is 1273 residues long for SARS-CoV-2. :) This is likely why Moderna refers to their product as mRNA-1273.
The full‐length of SARS‐CoV‐2 S is 1273 amino acid long with several functional domains and multiple proteolytic cleavage sites at S1/S2 boundary and S2' site.1
Also, at the end when we were doing our modeling exercise, I had read the number of doses per vax lot data wrong. It does not change the conclusion that there are ‘order of magnitude’ differences within the vax lots with respect to number of doses available. The following are the correct max and min values for number of doses per vax lot according to batch size and shipment numbers.
Maximum number of doses = 1,539,300 (There were 15,393 shipments of vax lot FL0007 with 100 doses per shipment.)
Minimum number of doses = 58,500 (There were 5 shipments of vax lot EP7533 with 11,700 doses per shipment.)
I actually prepared a slide deck for use in this podcast as sort of a ‘lecture format’, but I couldn’t screen share so I will leave the slides here. :) The slide deck is a really back to basics Biochem 101 course combined with %RNA integrity data leaks and evidence that this known low %RNA integrity is causing immunological chaos.
It may be that ‘fresher’ products do more damage and it may in turn be that this is the result of less degradation having ensued, ie: higher %RNA integrity → closer to full-length spike protein. Not sure yet.
I am currently looking into our unanswered questions concerning the effect of stratification by demographics, for example, and other neat stuff.
If you have cool ideas, pitch them in the comments. I will leave them open to all. :)
Stay tuned.
Zhu, C., He, G., Yin, Q., Zeng, L., Ye, X., Shi, Y., & Xu, W. (2021). Molecular biology of the SARs-CoV-2 spike protein: A review of current knowledge. Journal of medical virology, 93(10), 5729–5741. https://doi.org/10.1002/jmv.27132.
I listened to the RFKJR interview with Sasha Latypova and surmise that poor quality control by DOD’s contractors is the reason anybody is still alive out of 80% “jabbed” in the US (or whatever it is).
The ability to adhere a refrigerator magnet to one’s forehead seems to be an interesting side effect for a few. Might come in handy if you don’t mind the reason for it. I get queasy thinking about it.
Aside from that, the Society of Actuaries report cited by Ed Dowd suggests a connection between COVID shot outcomes and the cumulative effect of assault by childhood vaccines. My question is posed below in a comment posted on Igor’s sub stack. Just asking!
Thanks!
Prior post copied here:
The Society of Actuarials report posted by @Edward Dowd on GETTR shows a 100% spike in excess death for age 35 to 44 in Q3 ‘21. Age 35 was birth year 1986. This group effectively captures the escalation of childhood vaccines driven by the Vaccine Injury Compensation Act. This group was subsequently mandated by their employers when their busy boxes were replaced by laptops. Chronic immune suppression carried into adulthood that reacted in a catastrophic way to the COVID shots is a possible link to the enhanced vulnerability of younger folks to sudden death post vax. It tells of the inadequacy of all vaccine safety testing, the need to strip away legal Immunity from the manufacturers and to codify philosophical exemption to all vaccine requirements.
Hi Jessica, thanks for all your writing and analysis. In UK we noticed that calls to ambulances for collapse/syncope and cardiac arrest sky rocketed shortly after the regulator here changed the thawed shelf life of the Pfizer injection from 5 days to 30 days. That was the from about 21st May 2021. I understand that the FDA did the same in the USA at about the same time. I wonder how this longer thawed shelf life will affect RNA integrity and whether this is linked to the SAEs. It would be interesting to look at pre-May 2021 vs post-May 2021 for Pfizer. Ideally one would want to plot time since thawing against SAE frequency but I guess that data isn't available.