A fatal flaw exists in depending upon a single study to set clinical guidelines, especially when an ongoing heath crisis exists. Studies are designed using set protocols, while great clinicians learn to customize treatment for each individual patient. For example, Dr. Paul Marik who treats thousands of very complicated and sick patients in his ICU, discovered that his Delta patients carried a higher viral load than his original Wuhan alpha strain patients. (This study was performed when Delta was predominate.) Therefore from his experience with his very sick suffering real patients, he empirically increased the dose of ivermectin from 0.4 mg/kg (used in this study) to 0.6 mg/kg. He also realized that not every patient will respond adequately to a five day course (used exclusively in this study). If your patient is not improving, you administer the medication in whatever dose and for as many days as it takes for this patient to improve his O2 saturations. In real life, he also used multiple other treatment modalities for each unique patient. Another way of saying it is that a one-size-fits-all protocol may make sense in a digital AI theoretical medical universe, but will never achieve successful results like an intelligent, observant, caring, and experienced human physician.
EXCELLENT Analysis by a True scientist. I also hope you would comment on a point raised by some that this study did NOT use Ivermectin WITH Zinc but used Ivermectin by ITSELF only. Thanks.
I think the main problem is due to "open label bias"...
We start to smell a rat because the trial does not show the consistency you would expect (i.e., the same trend in all categories): so-called "disease progression" is up 20% in the IVM group, but Mechanical Ventilation is down 60%, ICU admission is down 30% and 28day mortality is down 70%. According to those secondary figures, significant or not, you would be dumb to refuse IVM.
But how did the "disease progression" figures come to be so out-of-proportion with the rest? Precisely because the study was "open label", which means that both the nurses/doctors and the patients knew who was taking the IVM and who who was not. I suggest that the nurses (and patients) would have been more anxious about "disease progression" among those receiving the IVM treatment - the faulty inference would be: they must be taking treatment because they are worse. As a result, the nurses and patients would have been more prompt to report symptoms that would allow them to receive earlier oxygen therapy, which would then be classified as "disease progression". The same bias did not play out in the secondary markers, because these treated patients were actually in a better condition than the untreated group.
The conclusion is not supported at all by the biased data. They should have had both groups taking tablets that looked the same (one group IVM and the other group placebo), and they should not have allowed the nurses or patients to know who was on IVM treatment and who was not. Results are spoiled by very poor study design!
My husband and I just got over Omicron. Have been on the D3, Zinc et all protocol for two years. When we got C, we took Ivermectin, prednisone, and antibiotic. Symptoms lasted three days each. We are both in our mid 70’s. Got the meds through a doc on line. Would do it again
I hate to say this, but maybe A.B. is not completely wrong here. At the flccc website, there are lots of videos and anecdotes about people who got Ivermectin and experienced almost instantaneous, miraculous recoveries. But what this study is showing, is that most patients (395 of 490 in this case) recover without progressing to severe status, with or without Ivermectin. So maybe the anecdotes about sudden recoveries are just coincidental?
If indeed Ivermectin is effective, it makes sense to me that it would take more than a few days to work. But that's not consistent with the flccc narrative.
In real world clinical practice, most patients wouldn't be taking Ivermectin alone. They'd also be getting vitamin D, and zinc, and probably quercetin and antiseptic mouth wash. Maybe that's a trial that someone should run.
Lat year I gave a friend my "Furious HD" protocol travel kit (I was headed home that day) that included 100mg doxycycline and zinc. She texted me in early December stating she tested positive for covid and had a 103 degree fever - her husband gave her one 12mg of Furious HD and doxy+zinc - her fever was gone in less than 12 hours and she was fully recovered in less than 3 days. Furious HD ALONE will not kick covid's a** yet combined with an antibiotic and zinc it will. Coincidence - I think not!!
This is a great analysis. I have a very difficult time reducing information this way so I can help others to think critically. I already used your clear breakdown of the concepts and stats several times today. I have to admit I am a Jessica Junky ( meant with complete intellectual adoration )… and look forward to your posts every day. Thank you so much for all you do!
Feb 19, 2022·edited Feb 20, 2022Liked by Jessica Rose
Thank you for making these complex ideas so easy to understand for the lay person. The search for the truth is incredibly difficult. Can you do the same for VAIDS? I can't be the only person married to a 3X vaxxed person. I'm deeply concerned and uncertain if this is even something to be concerned about.
Looks like you mixed up the denominators between HD and NonHD when calculating %death. Probably should also include 95% CI when calculating these differences. Although there is a trend in mortality reduction, it’s important to point out none of these differences were statistically significant. The numbers are just too small.
My husband and I just got over Omicron. Have been on the D3, Zinc et all protocol for two years. When we got C, we took Ivermectin, prednisone, and antibiotic. Symptoms lasted three days each. We are both in our mid 70’s. Got the meds through a doc on line. Would do it again
Alex Berenson are you reading, or still stuck in some imagined grudge against Dr. Robert Malone?
I ❤️Jessica Rose. 🇨🇦
Thank you for ALL that you are doing and for the laughs! (furious HD).
You are a treasure. And a leader.
Respect🙏🏻
Thank you for being real and working hard to understand the numbers. We appreciate you!!!
A fatal flaw exists in depending upon a single study to set clinical guidelines, especially when an ongoing heath crisis exists. Studies are designed using set protocols, while great clinicians learn to customize treatment for each individual patient. For example, Dr. Paul Marik who treats thousands of very complicated and sick patients in his ICU, discovered that his Delta patients carried a higher viral load than his original Wuhan alpha strain patients. (This study was performed when Delta was predominate.) Therefore from his experience with his very sick suffering real patients, he empirically increased the dose of ivermectin from 0.4 mg/kg (used in this study) to 0.6 mg/kg. He also realized that not every patient will respond adequately to a five day course (used exclusively in this study). If your patient is not improving, you administer the medication in whatever dose and for as many days as it takes for this patient to improve his O2 saturations. In real life, he also used multiple other treatment modalities for each unique patient. Another way of saying it is that a one-size-fits-all protocol may make sense in a digital AI theoretical medical universe, but will never achieve successful results like an intelligent, observant, caring, and experienced human physician.
EXCELLENT Analysis by a True scientist. I also hope you would comment on a point raised by some that this study did NOT use Ivermectin WITH Zinc but used Ivermectin by ITSELF only. Thanks.
I think the main problem is due to "open label bias"...
We start to smell a rat because the trial does not show the consistency you would expect (i.e., the same trend in all categories): so-called "disease progression" is up 20% in the IVM group, but Mechanical Ventilation is down 60%, ICU admission is down 30% and 28day mortality is down 70%. According to those secondary figures, significant or not, you would be dumb to refuse IVM.
But how did the "disease progression" figures come to be so out-of-proportion with the rest? Precisely because the study was "open label", which means that both the nurses/doctors and the patients knew who was taking the IVM and who who was not. I suggest that the nurses (and patients) would have been more anxious about "disease progression" among those receiving the IVM treatment - the faulty inference would be: they must be taking treatment because they are worse. As a result, the nurses and patients would have been more prompt to report symptoms that would allow them to receive earlier oxygen therapy, which would then be classified as "disease progression". The same bias did not play out in the secondary markers, because these treated patients were actually in a better condition than the untreated group.
The conclusion is not supported at all by the biased data. They should have had both groups taking tablets that looked the same (one group IVM and the other group placebo), and they should not have allowed the nurses or patients to know who was on IVM treatment and who was not. Results are spoiled by very poor study design!
My husband and I just got over Omicron. Have been on the D3, Zinc et all protocol for two years. When we got C, we took Ivermectin, prednisone, and antibiotic. Symptoms lasted three days each. We are both in our mid 70’s. Got the meds through a doc on line. Would do it again
I hate to say this, but maybe A.B. is not completely wrong here. At the flccc website, there are lots of videos and anecdotes about people who got Ivermectin and experienced almost instantaneous, miraculous recoveries. But what this study is showing, is that most patients (395 of 490 in this case) recover without progressing to severe status, with or without Ivermectin. So maybe the anecdotes about sudden recoveries are just coincidental?
If indeed Ivermectin is effective, it makes sense to me that it would take more than a few days to work. But that's not consistent with the flccc narrative.
In real world clinical practice, most patients wouldn't be taking Ivermectin alone. They'd also be getting vitamin D, and zinc, and probably quercetin and antiseptic mouth wash. Maybe that's a trial that someone should run.
Lat year I gave a friend my "Furious HD" protocol travel kit (I was headed home that day) that included 100mg doxycycline and zinc. She texted me in early December stating she tested positive for covid and had a 103 degree fever - her husband gave her one 12mg of Furious HD and doxy+zinc - her fever was gone in less than 12 hours and she was fully recovered in less than 3 days. Furious HD ALONE will not kick covid's a** yet combined with an antibiotic and zinc it will. Coincidence - I think not!!
You rock! I hate statistics too. You made it more than palatable.
This is a great analysis. I have a very difficult time reducing information this way so I can help others to think critically. I already used your clear breakdown of the concepts and stats several times today. I have to admit I am a Jessica Junky ( meant with complete intellectual adoration )… and look forward to your posts every day. Thank you so much for all you do!
Thank you for making these complex ideas so easy to understand for the lay person. The search for the truth is incredibly difficult. Can you do the same for VAIDS? I can't be the only person married to a 3X vaxxed person. I'm deeply concerned and uncertain if this is even something to be concerned about.
70% reduction in death. Hmmmm.... Yeah, but they had worse symptoms. Hmmm....
I'll take death. Yep, that's the ticket. A.B. is onto something.
Looks like you mixed up the denominators between HD and NonHD when calculating %death. Probably should also include 95% CI when calculating these differences. Although there is a trend in mortality reduction, it’s important to point out none of these differences were statistically significant. The numbers are just too small.
Thank you. Good read.
My husband and I just got over Omicron. Have been on the D3, Zinc et all protocol for two years. When we got C, we took Ivermectin, prednisone, and antibiotic. Symptoms lasted three days each. We are both in our mid 70’s. Got the meds through a doc on line. Would do it again