Reading “Turtles All the Way Down”, I was shocked to learn that the placebo control in vaccine trials is never neutral saline; instead, the placebo is always spiked with something toxic (usually another vaccine, sometimes an adjuvant) to raise the background rate of Adverse Events to hide any safety signal. Now it appears that the Governments/ Pharma complex did it again with eLNPs. Hard prison time for all involved in this atrocity!
As usual, you help us see deep into these studies. My brain didn't make the LNP connection when I first read your writings about the vaccine "trials". Thinking back, having LNP in the vaccine with no mRNA would explain the crazy stats in the trials. How long before our rulers actually start listening to you and others? Probably never! The horror they have created will be felt for at least a generation. Thanks for another great essay.
The Mother's Anthem is heartbreaking. Thank God she found Dr. B, but what to make of the total apathy and lack of compassion of the medical community at large?
I agree, it’s terrifying! However, I think the more we share stories like A Mother’s Anthem; and Dr B’s compassion-then hopefully more Drs will step up and start helping and healing the injured.
Thank you Jessica for bringing the issue of potential LNP toxicity back into the light. From a super high level view, this was one of the reason's I refused to take the shots way, way before they were even ready to be given - the employment of two totally new modalities together in these shots, mRNA + LNP vectoring, was nuts on a first principles basis. In my industry (semiconductor manufacturing) you never want to introduce two major changes to an otherwise stable process at the same time, because if you then see undesirable effects, you are unable to deconvolute whether the problem is one, the other, or some negative interaction between the two. Yet many of my colleagues with PhD after their name invited this risky experiment into their bodies willingly.
My thoughts were really cemented in mid-2021 when I saw this paper;
Title: Novel lipid nanoparticle provides potent SARS-CoV-2 mRNA vaccine at low dose with low local reactogenicity, high thermostability and limited systemic biodistribution
One only needs to read the abstract below to realize that, while they were planning to inject millions, if not billions of people around the world with this shitty, first generation LNP vector, better and safer versions are certainly possible and were already on the lab bench. Fuck that.
Abstract
"Concerns with current mRNA Lipid Nanoparticle (LNP) systems include dose-limiting reactogenicity, adverse events that may be partly due to systemic off target expression of the immunogen, and a very limited understanding of the mechanisms responsible for the frozen storage requirement. We applied a new rational design process to identify a novel multiprotic ionizable lipid, called C24, as the key component of the mRNA LNP delivery system. We show that the resulting C24 LNP has a multistage protonation behavior resulting in greater endosomal protonation and greater translation of an mRNA-encoded luciferase reporter after intramuscular (IM) administration compared to the standard reference MC3 LNP. Off-target expression in liver after IM administration was reduced 6 fold for the C24 LNP compared to MC3. Neutralizing titers in immunogenicity studies delivering a nucleoside-modified mRNA encoding for the diproline stabilized spike protein immunogen were 10 fold higher for the C24 LNP versus MC3, and protection against viral challenge in a SARS-CoV-2 mouse model occurred at a very low 0.25 µg prime/boost dose of the same immunogen in the C24 LNP. Injection site inflammation was notably reduced for C24 compared to MC3. In addition, we found the C24 LNP to be entirely stable in bioactivity and mRNA integrity when stored at 4 ºC for at least 19 days. Storage at higher temperatures reduced both bioactivity and mRNA integrity, but less so for C24 than MC3, and in a manner consistent with the phosphodiester transesterification reaction mechanism of mRNA cleavage. The higher potency, lower injection site inflammation, and higher stability of the C24 LNP present important advancements in the evolution mRNA vaccine delivery."
My sister has skin that keloids. I don’t know anything about this but she got the vaxx and then she had dizziness when standing, abnormally high b12, and now bad knees. She’s in her 30s. Bad knees young were inherited from my mother I think- but after the shot now my sisters knees are so bad she sees a PT. They don’t know why. They make an awful cracking sound going upstairs. I wonder if any of this is related to the fact she is predisposed to keloid. I’m obviously worried but she won’t listen. She was athletic, a runner. She thinks it’s “long Covid.”
Are LNP’s used in monoclonal antibodies (e.g., Regeneron)? Still trying to sort whether mAbs might cause unforeseen problems in those who avoided the vax. Thank you!
No, the LNP's are employed as a means to get the mRNA into your cells. Antibodies do their jobs in your bloodstream, and are hence generally given via IV infusion;
At an infectious disease conference 1 or 2 years bc (before Covid) one of the lecturers noted that 'flu shots don't work very well in this over 65. The immediate question from one of the attendees was "Can we give ourselves four shots?"
The answer was no, with some explanation based on concentration, but now that I have thought about it was probably related to adjuvant.
In the subsequent years the shots for over 65's have been different the the normal adult dose.
Reading “Turtles All the Way Down”, I was shocked to learn that the placebo control in vaccine trials is never neutral saline; instead, the placebo is always spiked with something toxic (usually another vaccine, sometimes an adjuvant) to raise the background rate of Adverse Events to hide any safety signal. Now it appears that the Governments/ Pharma complex did it again with eLNPs. Hard prison time for all involved in this atrocity!
As usual, you help us see deep into these studies. My brain didn't make the LNP connection when I first read your writings about the vaccine "trials". Thinking back, having LNP in the vaccine with no mRNA would explain the crazy stats in the trials. How long before our rulers actually start listening to you and others? Probably never! The horror they have created will be felt for at least a generation. Thanks for another great essay.
Thank you for all you are doing. I have been very curious about LNP’s-what percentage of people have antibodies to phospholipids and PEG? Please read A Mothers’s Anthem substack-how one mom is saving her son’s life after a PEG reaction. https://open.substack.com/pub/amothersanthem/p/the-shot-heard-around-the-world?r=nzeud&utm_medium=ios&utm_campaign=post
The Mother's Anthem is heartbreaking. Thank God she found Dr. B, but what to make of the total apathy and lack of compassion of the medical community at large?
I agree, it’s terrifying! However, I think the more we share stories like A Mother’s Anthem; and Dr B’s compassion-then hopefully more Drs will step up and start helping and healing the injured.
I too have been wondering if the LNP's may cause amyloids.
As "a jab in every arm" Bill said to Faucho:
"From ashes to ashes and from dust to dust,
If the spikes don't get you then the LNPs must."
Thank you Jessica for bringing the issue of potential LNP toxicity back into the light. From a super high level view, this was one of the reason's I refused to take the shots way, way before they were even ready to be given - the employment of two totally new modalities together in these shots, mRNA + LNP vectoring, was nuts on a first principles basis. In my industry (semiconductor manufacturing) you never want to introduce two major changes to an otherwise stable process at the same time, because if you then see undesirable effects, you are unable to deconvolute whether the problem is one, the other, or some negative interaction between the two. Yet many of my colleagues with PhD after their name invited this risky experiment into their bodies willingly.
My thoughts were really cemented in mid-2021 when I saw this paper;
https://www.researchsquare.com/article/rs-798453/v1
Title: Novel lipid nanoparticle provides potent SARS-CoV-2 mRNA vaccine at low dose with low local reactogenicity, high thermostability and limited systemic biodistribution
One only needs to read the abstract below to realize that, while they were planning to inject millions, if not billions of people around the world with this shitty, first generation LNP vector, better and safer versions are certainly possible and were already on the lab bench. Fuck that.
Abstract
"Concerns with current mRNA Lipid Nanoparticle (LNP) systems include dose-limiting reactogenicity, adverse events that may be partly due to systemic off target expression of the immunogen, and a very limited understanding of the mechanisms responsible for the frozen storage requirement. We applied a new rational design process to identify a novel multiprotic ionizable lipid, called C24, as the key component of the mRNA LNP delivery system. We show that the resulting C24 LNP has a multistage protonation behavior resulting in greater endosomal protonation and greater translation of an mRNA-encoded luciferase reporter after intramuscular (IM) administration compared to the standard reference MC3 LNP. Off-target expression in liver after IM administration was reduced 6 fold for the C24 LNP compared to MC3. Neutralizing titers in immunogenicity studies delivering a nucleoside-modified mRNA encoding for the diproline stabilized spike protein immunogen were 10 fold higher for the C24 LNP versus MC3, and protection against viral challenge in a SARS-CoV-2 mouse model occurred at a very low 0.25 µg prime/boost dose of the same immunogen in the C24 LNP. Injection site inflammation was notably reduced for C24 compared to MC3. In addition, we found the C24 LNP to be entirely stable in bioactivity and mRNA integrity when stored at 4 ºC for at least 19 days. Storage at higher temperatures reduced both bioactivity and mRNA integrity, but less so for C24 than MC3, and in a manner consistent with the phosphodiester transesterification reaction mechanism of mRNA cleavage. The higher potency, lower injection site inflammation, and higher stability of the C24 LNP present important advancements in the evolution mRNA vaccine delivery."
Fantastic! Following the breadcrumbs is righteous. SPEAK!!!
My sister has skin that keloids. I don’t know anything about this but she got the vaxx and then she had dizziness when standing, abnormally high b12, and now bad knees. She’s in her 30s. Bad knees young were inherited from my mother I think- but after the shot now my sisters knees are so bad she sees a PT. They don’t know why. They make an awful cracking sound going upstairs. I wonder if any of this is related to the fact she is predisposed to keloid. I’m obviously worried but she won’t listen. She was athletic, a runner. She thinks it’s “long Covid.”
bit by bit by bit we are learning the truth....
I have heard, but not confirmed, that the Trudeau Family Foundation holds a major stake in Acuitas.
Thus a win-win for Justin when he mandates and spends hundreds of millions of taxpayer's money on vaxxing programmes.
Are LNP’s used in monoclonal antibodies (e.g., Regeneron)? Still trying to sort whether mAbs might cause unforeseen problems in those who avoided the vax. Thank you!
No, the LNP's are employed as a means to get the mRNA into your cells. Antibodies do their jobs in your bloodstream, and are hence generally given via IV infusion;
https://my.clevelandclinic.org/health/treatments/22246-monoclonal-antibodies
At an infectious disease conference 1 or 2 years bc (before Covid) one of the lecturers noted that 'flu shots don't work very well in this over 65. The immediate question from one of the attendees was "Can we give ourselves four shots?"
The answer was no, with some explanation based on concentration, but now that I have thought about it was probably related to adjuvant.
In the subsequent years the shots for over 65's have been different the the normal adult dose.